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Antibiotic resistance: World on cusp of 'post-antibiotic era

Discussions related to the physiological and psychological effects of peak oil on our members and future generations.

Re: Antibiotic resistance: World on cusp of 'post-antibiotic

Unread postby vtsnowedin » Tue 07 Jun 2016, 15:50:14

$this->bbcode_second_pass_quote('Tanada', 'I') predict that when the first child, probably a poor inner city kid, dies of antibiotic resistant Pertussis (whooping cough), it will set off a kind of alarm media firestorm like you have not yet seen in the USA. We like to believe childhood illnesses have been eliminated and are no longer a threat. It was only three generations ago, 75 years more or less, that a quarter of all children born in this country died before reaching adulthood from one disease or another.

The thing is, diseases like Pertussis that could be treated with antibiotics never had an effort put into immunization the same way the viral diseases like Small Pox and Rubella (German measles) did. The viral diseases got all the immunization work done precisely because they could not be treated with antibiotics that attack bacterial infections. The children who have been immunized will be safe from MMR (Mumps Measles and Rubella) and Varicella (chicken pox) and Polio, and even that rare bacteria that does have an immunization Scarlet Fever. But for all the other child hood bacterial diseases they will be defenseless, especially growing up in a culture that limits outdoor play and skinned knees as being too scary to contemplate.

Make no mistake, I do not want to see several million kids in this country catch bacterial diseases and die, but now that resistant bacteria have made it to our shores the time to develop vaccines is growing extremely short.
I think you have some facts wrong there Tanada. My children were all vaccinated against pertussis as infants. It came in combination with the MMR you mention but they got it.
Edit to add this link.
http://healthvermont.gov/hc/imm/documen ... ements.pdf
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Re: Antibiotic resistance: World on cusp of 'post-antibiotic

Unread postby Subjectivist » Tue 07 Jun 2016, 19:26:30

$this->bbcode_second_pass_quote('onlooker', 'I') am wondering if this information on this thread can be extrapolated to claim that this situation will make a world-wide Pandemic much more likely as more vulnerable sickly people will be around and also a particularly virulent bacteria can arise from all this dramatic evolution in resistant bacteria that can be the ONE to initiate a Pandemic?


Speaking of pandemics, good old Black Death that cut the European population by between a third and half is caused by a bacteria, Yersinia Pestis. The biggest causes of mass transmission are crowded conditions with limited hygiene and prolific rat populations.
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Re: Antibiotic resistance: World on cusp of 'post-antibiotic

Unread postby Tanada » Tue 07 Jun 2016, 22:21:19

$this->bbcode_second_pass_quote('vtsnowedin', '')$this->bbcode_second_pass_quote('Tanada', 'I') predict that when the first child, probably a poor inner city kid, dies of antibiotic resistant Pertussis (whooping cough), it will set off a kind of alarm media firestorm like you have not yet seen in the USA. We like to believe childhood illnesses have been eliminated and are no longer a threat. It was only three generations ago, 75 years more or less, that a quarter of all children born in this country died before reaching adulthood from one disease or another.

The thing is, diseases like Pertussis that could be treated with antibiotics never had an effort put into immunization the same way the viral diseases like Small Pox and Rubella (German measles) did. The viral diseases got all the immunization work done precisely because they could not be treated with antibiotics that attack bacterial infections. The children who have been immunized will be safe from MMR (Mumps Measles and Rubella) and Varicella (chicken pox) and Polio, and even that rare bacteria that does have an immunization Scarlet Fever. But for all the other child hood bacterial diseases they will be defenseless, especially growing up in a culture that limits outdoor play and skinned knees as being too scary to contemplate.

Make no mistake, I do not want to see several million kids in this country catch bacterial diseases and die, but now that resistant bacteria have made it to our shores the time to develop vaccines is growing extremely short.
I think you have some facts wrong there Tanada. My children were all vaccinated against pertussis as infants. It came in combination with the MMR you mention but they got it.
Edit to add this link.
http://healthvermont.gov/hc/imm/documen ... ements.pdf


Mea Culpa, the graph I was looking at was for children whose parents chose not to have them vaccinated. Last year there was a big Measles outbreak on the OSU campus do to the poor vaccination history of some of the students, and this past winter I had to reschedule a doctors appointment because my physician came down with Whooping Cough. A patient did not tell him they were being tested for Pertussis by the 24 hour clinic until after he had completed the exam and he had to go on antibiotics for ten days after testing positive himself.

So for the most part the two deadliest bacterial childhood diseases, Pertussis and Scarlet Fever, do have vaccines but they are no longer being universally administered thanks to the anti Vax movement.
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Re: Antibiotic resistance: World on cusp of 'post-antibiotic

Unread postby onlooker » Wed 08 Jun 2016, 07:29:49

$this->bbcode_second_pass_quote('', 'S')peaking of pandemics, good old Black Death that cut the European population by between a third and half is caused by a bacteria, Yersinia Pestis. The biggest causes of mass transmission are crowded conditions with limited hygiene and prolific rat populations.

Umm, that seems to be the conditions in many urban slums around the world. Yikes :(
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Re: Antibiotic resistance: World on cusp of 'post-antibiotic

Unread postby Tanada » Wed 08 Jun 2016, 07:56:52

$this->bbcode_second_pass_quote('onlooker', '')$this->bbcode_second_pass_quote('', 'S')peaking of pandemics, good old Black Death that cut the European population by between a third and half is caused by a bacteria, Yersinia Pestis. The biggest causes of mass transmission are crowded conditions with limited hygiene and prolific rat populations.

Umm, that seems to be the conditions in many urban slums around the world. Yikes :(


Weird historical footnote, the United States Army Air Corp of WW II actually proposed dropping infected rats and mice on Japan during the war to spread the plague as a form of biological warfare. Turns out you can drop a mouse or young rat from any altitude without a parachute, they are such low mass to drag ratio that they will not be injured by a fall of any height. It also turns out that fleas require a certain level of air pressure to survive and if your aircraft goes up over about 12,000 feet all the fleas that carry the disease die. It is possible that this is one of the reasons people living on high mountains have always been reputed to be healthy compared to the general population, neither mosquito's nor fleas can live and pass diseases at low air pressures.
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Re: Antibiotic resistance: World on cusp of 'post-antibiotic

Unread postby onlooker » Thu 09 Jun 2016, 19:37:58

$this->bbcode_second_pass_quote('Tanada', '')$this->bbcode_second_pass_quote('onlooker', '')$this->bbcode_second_pass_quote('', 'S')peaking of pandemics, good old Black Death that cut the European population by between a third and half is caused by a bacteria, Yersinia Pestis. The biggest causes of mass transmission are crowded conditions with limited hygiene and prolific rat populations.

Umm, that seems to be the conditions in many urban slums around the world. Yikes :(


Weird historical footnote, the United States Army Air Corp of WW II actually proposed dropping infected rats and mice on Japan during the war to spread the plague as a form of biological warfare. Turns out you can drop a mouse or young rat from any altitude without a parachute, they are such low mass to drag ratio that they will not be injured by a fall of any height. It also turns out that fleas require a certain level of air pressure to survive and if your aircraft goes up over about 12,000 feet all the fleas that carry the disease die. It is possible that this is one of the reasons people living on high mountains have always been reputed to be healthy compared to the general population, neither mosquito's nor fleas can live and pass diseases at low air pressures.

Good to know if the plague happens to make an appearance in my neck of the woods. I would be literally heading for the hills. Not my idea of a fun way to die. :twisted:
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Re: Antibiotic resistance: World on cusp of 'post-antibiotic

Unread postby onlooker » Wed 03 Aug 2016, 18:24:29

http://www.latimes.com/science/sciencen ... story.html
A 'slow catastrophe' unfolds as the golden age of antibiotics comes to an end
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Re: Antibiotic resistance: World on cusp of 'post-antibiotic

Unread postby Newfie » Wed 03 Aug 2016, 22:16:13

$this->bbcode_second_pass_quote('', 'U')ntil very recently, few made the connection between antibiotic use in individual cases and the emergence of antibiotic resistance, said Dr. Susan Bleasdale, an infection-control expert at the University of Illinois in Chicago. Patients with earaches, sinus pressure and sore throats demanded antibiotics, and physicians tended to oblige.


Statements like this piss me off. I'm no freaking genius and Ive know about this since high school or shortly thereafter.

The plain truth is we damn well know about it and do nothing. We created the problem. Worse, our trusted doctors and pharma industry created the problem. Just as we they now perpetuate the use of addictive pain killers.

Makes RJR sound positively humanitarian.

I like simple, blunt statements like....
Yeah, we knew, we did nothing but serve our greed, now billions will die. On the bright side it will ease over population.

It's almost like we WANT to off ourselves as a species, but can't admit it.
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Re: Antibiotic resistance: World on cusp of 'post-antibiotic

Unread postby onlooker » Wed 03 Aug 2016, 22:25:42

yeah, we certainly have gone along certain paths that can all be called suicidal. Makes one wonder about our species and our intelligence.
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Re: Antibiotic resistance: World on cusp of 'post-antibiotic

Unread postby dissident » Sun 07 Aug 2016, 17:25:58

$this->bbcode_second_pass_quote('pstarr', 'T')he thread proposition is ridiculous. Antibiotic resistance is still confined to few hospital populations and limited impoverished areas without proper health codes or practices.

But in a related vein, asthma seems to be a chronic chlamydia pneumoniae-associated bacterial infection. Effectively treated with azithromycin.


Do you have a link? There is ample evidence that fine mode aerosols (e.g. vehicle emissions) are a key element in asthama.
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Do Amish hold clue to preventing asthma in children?

Unread postby dolanbaker » Sun 07 Aug 2016, 17:50:11

$this->bbcode_second_pass_quote('', 'h')ttp://www.bbc.com/news/health-36974348

The Amish community in the US has long been famous for shunning modern technology and preserving traditional ways of life, using horses for farming and for transport.

Now it appears that their closer contact with animals could have an unexpected benefit - preventing asthma in children.

A new study from the US compared the Amish with a similar community, the Hutterites, who use more modern farming methods.

Both groups have similar genetic ancestry and follow similar diets, but researchers found that childhood asthma rates differed strongly.

About 5% of Amish schoolchildren tested in the study had asthma compared with 21.3% of the Hutterite children.

The study in the New England Journal of Medicine suggested that children's immune systems in the Amish community were being bolstered by house dust that contained more microbes from farm animals.
Barns closer to homes

The findings echo other studies that have suggested that a lack of early exposure to microbes, caused by modern hygiene, increases the risk of allergy.

The dust found in Amish homes was "much richer in microbial products," the study said.

"Neither the Amish nor the Hutterites have dirty homes," said study co-author Carole Ober, professor and chairman of human genetics at the University of Chicago.

"Both are tidy. The Amish barns, however, are much closer to their homes. Their children run in and out of them, often barefoot, all day long. There's no obvious dirt in the Amish homes, no lapse of cleanliness. It's just in the air and in the dust."

Blood tests from 30 children from each community, aged seven to 14, showed that the Amish youngsters had more neutrophils - white blood cells crucial to fighting infections.

Just goes to prove that a busy immune system is a healthy one.
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Re: Antibiotic resistance: World on cusp of 'post-antibiotic

Unread postby dissident » Sun 07 Aug 2016, 19:44:07

$this->bbcode_second_pass_quote('pstarr', '')$this->bbcode_second_pass_quote('dissident', '')$this->bbcode_second_pass_quote('pstarr', 'T')he thread proposition is ridiculous. Antibiotic resistance is still confined to few hospital populations and limited impoverished areas without proper health codes or practices.

But in a related vein, asthma seems to be a chronic chlamydia pneumoniae-associated bacterial infection. Effectively treated with azithromycin.


Do you have a link? There is ample evidence that fine mode aerosols (e.g. vehicle emissions) are a key element in asthama.

While there is evidence that aerosols, pollen allergies, and subsequent infections can promote asthama attacks, the underlying chronic syndrome that initiates and underlies attacks has apparently remained mostly poorly studied and understood.

See David L. Hahn and his work.


http://www.jabfm.org/content/25/4/442.full

Does not look conclusive.

One of the theories why eastern Europeans living under communism had lower asthma rates was that they breathed "dirtier" air as children. This BS theory did have some value since it pointed to the air as an important factor. After the import of the western lifestyle, where every dog and its owner has a car, asthma rates have begun reach western levels. Cities that had little car traffic in the 1970s are now gridlocked with traffic. If asthma was bacterial/viral it would not show such a dependence.

It seems there are different types of asthma and a bacterial variant looks like a plausible hypothesis. In recent years there have been other discoveries of the role of bacteria. About 40% of all chronic back pain is due to acne bacteria that enter the system through inflamed gums and set up shop in the spinal disks. The bacteria cause additional inflammation that leads to more capillary growth and easier access to deeper parts of the disks.

http://thebrainbank.scienceblog.com/201 ... back-pain/
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Re: Antibiotic resistance: World on cusp of 'post-antibiotic

Unread postby onlooker » Mon 08 Aug 2016, 09:29:40

Can I ask you guys if we are seeing now a genetic influence or basis to asthma and also allergies? I ask as my wife and I have a friend whose son was practically born with both asthma and allergies
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Re: Antibiotic resistance: World on cusp of 'post-antibiotic

Unread postby dissident » Mon 08 Aug 2016, 18:48:29

$this->bbcode_second_pass_quote('onlooker', 'C')an I ask you guys if we are seeing now a genetic influence or basis to asthma and also allergies? I ask as my wife and I have a friend whose son was practically born with both asthma and allergies


I will go out on a limb and say that epigenetics is the issue. Genetics plays a role, but unless we are undergoing some rapid mutations, there is way too much manifestation of various diseases and syndromes that have a genetic link. It looks to me like all sorts of man-made factors are starting to interfere with normal genetic activity and are causing the turning on and off of genes that would, under natural conditions, stay dormant.

Epigenetics is not really widely understood or appreciated. It is like a layer of DNA functionality that does not require pre-coding. The human genome project was somewhat predicated on the wrong assumption. The DNA is not a recipe for our system. It is more like a set of constraints in a system with many more degrees of freedom. The activation of these extra degrees of freedom by environmental factors is scary. We have turned the world into a toilet for molecules that did not exist 100 years ago. These molecules are not simple inorganic ones but complex organic ones that have a higher level of functionality (interaction with our biochemistry).

https://aacijournal.biomedcentral.com/a ... 1492-10-27
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Re: Antibiotic resistance: World on cusp of 'post-antibiotic

Unread postby onlooker » Tue 09 Aug 2016, 00:21:09

Umm interesting it makes one wonder about something like GMO,s , my cursory reading indictates they are not safe at all. The larger point you stress is so relevant to the world we live in now. A corollary to this point is how can our bodies handle the massive amount of unnatural inorganic and organic substances we are being exposed to and ingesting. This is amounting to being slowly poisoned to Death.
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Re: Antibiotic resistance: World on cusp of 'post-antibiotic

Unread postby Newfie » Tue 09 Aug 2016, 08:21:15

Dis,
Thanks for that post. My Wife comes across epigenetics occasionally in here professional reading regarding emotional disturbance. A fascinating aspect is that the change of state can pass to succeeding generations.
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Re: Antibiotic resistance: World on cusp of 'post-antibiotic

Unread postby Kylon » Tue 09 Aug 2016, 21:08:35

Has anybody heard about bacteriophages? Basically viruses that infect and eat bacteria.

If safe ones could be developed, then they'd provide a cheap means of antibiotics as one application to the appropriate bacteria would rapidly proliferate and infect all of the bacteria of that type until that bacteria were dead.

They also could, in theory, mutate and evolve faster than bacteria due to greater numbers and a shorter life cycle. This in turn would make resistance to bacteriophages less likely to happen.

The downside is the bacteriophages, if not properly developed and screened so that they can't/won't infect humans might become another source of pandemic.

Just something to think about.
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Re: Antibiotic resistance: World on cusp of 'post-antibiotic

Unread postby Tanada » Tue 09 Aug 2016, 22:49:36

$this->bbcode_second_pass_quote('Kylon', 'H')as anybody heard about bacteriophages? Basically viruses that infect and eat bacteria.

If safe ones could be developed, then they'd provide a cheap means of antibiotics as one application to the appropriate bacteria would rapidly proliferate and infect all of the bacteria of that type until that bacteria were dead.

They also could, in theory, mutate and evolve faster than bacteria due to greater numbers and a shorter life cycle. This in turn would make resistance to bacteriophages less likely to happen.

The downside is the bacteriophages, if not properly developed and screened so that they can't/won't infect humans might become another source of pandemic.

Just something to think about.


Ever hear of the cancer virus? It is a proven fact that occasionally for short periods of time a particular virus strain will develop that favors cancer cells as its host, preventing the cancer cell from reproducing itself and on occasion killing it. The problem with engineering a virus to target a particular cell like a certain bacteria or a certain cancer is, the genetics of the target vary from generation to generation. When the virus evolves to attack the new variation it might also attack the healthy human cells as well, which makes the risk awfully high.
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