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Antibiotic resistance: World on cusp of 'post-antibiotic era

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Antibiotic resistance: World on cusp of 'post-antibiotic era

Postby dolanbaker » Thu 19 Nov 2015, 08:34:48

This has been a long term worry of mine, and now it looks like it may actually become a reality.
All we need now is some group of nutters to isolate this bacteria, synthesise it with a common bacterial infectious disease and release it into the "wild".

Could have the potential of decimating the world's population.
$this->bbcode_second_pass_quote('', '
')http://www.bbc.co.uk/news/health-34857015
The world is on the cusp of a "post-antibiotic era", scientists have warned after finding bacteria resistant to drugs used when all other treatments have failed.

They identified bacteria able to shrug off the drug of last resort - colistin - in patients and livestock in China.

They said that resistance would spread around the world and raised the spectre of untreatable infections.

It is likely resistance emerged after colistin was overused in farm animals.

Bacteria becoming completely resistant to treatment - also known as the antibiotic apocalypse - could plunge medicine back into the dark ages.
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Re: Antibiotic resistance: World on cusp of 'post-antibiotic

Postby Newfie » Thu 19 Nov 2015, 08:36:23

That could be a cure for over shoot.

Are we the patient or the bug?

A matter of perspective. :cry:
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Antibiotic resistance: World on cusp of 'post-antibiotic era

Postby GHung » Thu 19 Nov 2015, 10:12:19

Nature deals with overshoot in many ways. Too bad our cleverness isn't tempered with wisdom and moderation in all things......

$this->bbcode_second_pass_quote('', '[')b]The world is on the cusp of a "post-antibiotic era", scientists have warned after finding bacteria resistant to drugs used when all other treatments have failed.

They identified bacteria able to shrug off the drug of last resort - colistin - in patients and livestock in China.

They said that resistance would spread around the world and raised the spectre of untreatable infections.

It is likely resistance emerged after colistin was overused in farm animals.

Bacteria becoming completely resistant to treatment - also known as the antibiotic apocalypse - could plunge medicine back into the dark ages.

Common infections would kill once again, while surgery and cancer therapies, which are reliant on antibiotics, would be under threat.

Key players

Chinese scientists identified a new mutation, dubbed the MCR-1 gene, that prevented colistin from killing bacteria.

The report in the Lancet Infectious Diseases showed resistance in a fifth of animals tested, 15% of raw meat samples and in 16 patients.

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More: http://www.bbc.com/news/health-34857015
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Re: Antibiotic resistance: World on cusp of 'post-antibiotic

Postby Tanada » Thu 19 Nov 2015, 10:44:07

The scary thing to me is, Doctors have horribly over prescribed antibiotics and patients have frequently failed to follow directions when taking them. Add in that unmetabolised antibiotics enter the waste stream and encourage resistance in the bacteria of all types in the sewage treatment system.

Everything from Heliobactor Pylori (ulcer causing bacteria) to Diphtheria that used to kill one in ten children are becoming antibiotic resistant. That means you can either get vaccinated, which many people oppose, or risk a constant death rate from those bacterial infections that will soon be completely resistant to external treatment. Of course vaccines work because they prime your bodies immune system, and many people managed to fight off the infections even without external aid, but ultimately it will be back to you verses the entire world of millions of types of bacteria. Most have little effect or counter balance each other, but some are very bad no matter how you slice it. Like Scarlett Fever. Or Bacterial Pneumonia. Staphylococcus. E. Coli. Salmonella. Meningitis.
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Re: Antibiotic resistance: World on cusp of 'post-antibiotic

Postby Subjectivist » Thu 19 Nov 2015, 11:14:51

Great, as far as I know nobody has developed vaccines for most of those diseases because they have assumed antibiotics made vaccines redundant. How long will it take to develop several hundred new vaccines and convince the public to accept them?
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Re: Antibiotic resistance: World on cusp of 'post-antibiotic

Postby Newfie » Thu 19 Nov 2015, 16:54:59

My understanding is that in India many of our prescription antibiotics are available over the counter and are widely miss used. Is that true?
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Re: Antibiotic resistance: World on cusp of 'post-antibiotic

Postby Subjectivist » Thu 19 Nov 2015, 17:44:44

$this->bbcode_second_pass_quote('Newfie', 'M')y understanding is that in India many of our prescription antibiotics are available over the counter and are widely miss used. Is that true?


Google is your friend.
http://www.nature.com/news/india-moves- ... ce-1.11392
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Re: Antibiotic resistance: World on cusp of 'post-antibiotic

Postby Newfie » Thu 19 Nov 2015, 20:53:43

Ah, so it is, thanks.
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Re: Antibiotic resistance: World on cusp of 'post-antibiotic

Postby SeaGypsy » Fri 20 Nov 2015, 00:46:30

This was the case all over Asia until very recently. I self prescribed some Amoxyclav (hospital grade antibiotic) a few years ago from a chemist in the Philippines. A year or so later the same chemist died from a resistance encephalitic bacteria, dead a day after she showed signs of unwellness. Later on it came out that she had been daily dosing Amoxyclav for a few years, as a preventative- obviously with no concept of how this affects all the other bugs in our bodies. She learned this trick from the local prostitutes. Do the math.

In the last year or so all ASEAN countries have introduced prescription only for antibiotics- some improvement.
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Re: Antibiotic resistance: World on cusp of 'post-antibiotic

Postby Tanada » Fri 20 Nov 2015, 09:11:43

$this->bbcode_second_pass_quote('SeaGypsy', 'T')his was the case all over Asia until very recently. I self prescribed some Amoxyclav (hospital grade antibiotic) a few years ago from a chemist in the Philippines. A year or so later the same chemist died from a resistance encephalitic bacteria, dead a day after she showed signs of unwellness. Later on it came out that she had been daily dosing Amoxyclav for a few years, as a preventative- obviously with no concept of how this affects all the other bugs in our bodies. She learned this trick from the local prostitutes. Do the math.

In the last year or so all ASEAN countries have introduced prescription only for antibiotics- some improvement.


IMO this is closing the barn door after the horses have fled. Like any technology antibiotics are morally neutral, like Fission they can be used for sensible purposes or stupid purposes. Anyone taking any antibiotic prophylacticly is turning themselves into a resistant bacteria farm. Sooner or later they will breed bacteria resistant to whatever they are taking.
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Re: Antibiotic resistance: World on cusp of 'post-antibiotic

Postby ritter » Fri 20 Nov 2015, 12:58:16

Kind of an interesting twist on the Tragedy of the Commons. We continue to do what is best for us individually, neglecting the whole. Then the whole becomes so rotten, it no longer supports the individual. Only then do we begin to see the errors of our ways. Maybe.

I've been aware of this for 20 years, since reading Laurie Garrett's The Coming Plague.
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Re: Antibiotic resistance: World on cusp of 'post-antibiotic

Postby Newfie » Fri 20 Nov 2015, 13:06:42

$this->bbcode_second_pass_quote('ritter', 'K')ind of an interesting twist on the Tragedy of the Commons. We continue to do what is best for us individually, neglecting the whole. Then the whole becomes so rotten, it no longer supports the individual. Only then do we begin to see the errors of our ways. Maybe.

I've been aware of this for 20 years, since reading Laurie Garrett's The Coming Plague.


Interesting thought. Could probably apply that to a wider range of applications and trends.
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Re: Antibiotic resistance: World on cusp of 'post-antibiotic

Postby AdTheNad » Sat 21 Nov 2015, 05:43:43

Everyone is talking about over use by humans, which is clearly very bad, but I want to know why a drug of last resort is being given to farm animals.
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Re: Antibiotic resistance: World on cusp of 'post-antibiotic

Postby davep » Sat 21 Nov 2015, 05:57:44

$this->bbcode_second_pass_quote('AdTheNad', 'E')veryone is talking about over use by humans, which is clearly very bad, but I want to know why a drug of last resort is being given to farm animals.


I agree entirely. It's apparently because they gain weight faster, so we're rushing headlong towards the post-antibiotic world because of farmers' rights to profits. They even put it in the feed, for Christ's sake https://www.udel.edu/chem/C465/senior/fall98/AntibiotFood2/pros_cons.html
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Re: Antibiotic resistance: World on cusp of 'post-antibiotic

Postby AgentR11 » Sat 21 Nov 2015, 12:44:44

$this->bbcode_second_pass_quote('Tanada', 'T')he scary thing to me is, Doctors have horribly over prescribed antibiotics and patients have frequently failed to follow directions when taking them. Add in that unmetabolised antibiotics enter the waste stream and encourage resistance in the bacteria of all types in the sewage treatment system.


This really can't be over emphasized. Doctors, especially in a fee for service model like the US with high litigation exposure, are very vulnerable to the temptation to not only prescribe antibiotics, but also to prescribe fairly high up on the food chain of antibiotics. Patients don't come in and say, Doc, I have a cold, hack hack, sneeze sneeze, ewww you got that on my lab coat. No, patients come in and say, "Doc, I need some SUPERmycin, cutie on TV said so." The instance of refusal to prescribe is much more challenging than just writing the script. The drug is more or less harmless in its single usage, mild risks, and the patient goes away happy; and he'll get better even if you prescribed sugar pills. And the patient gets a positive reinforcement in the doctor saying "ok", and honestly, any nagging cuts and bruises will heal up quite fast, and the patient does get well, so double down dose of positive reinforcement for repeat performance.

But of course... they don't take the whole card, they feel better, they stop, they stay well. And whatever bacteria that survived in their lungs, sinuses, etc, end up supplied with a substantial but non-lethal evolutionary selection pressure for immunity to the drug. Patient then walks in an office building and turns a door knob. AgentR follows shortly thereafter, nursing the aftereffects of influence, and grabs said knob. AgentR being, an idiot, rubs his eyes whenever they itch, because that's what humans do. AgentR now has a lung infection that is immune to SUPERmycin. TY, come again, be sure to tip the undertaker on the way out.

Now, AgentR's trevails aren't particularly important, post reproductive age, gimping along, kid is basically an adult and well provided for. But that bacteria's immunity is a big deal. Because once its immune, it doesn't stop being immune.

I don't know that I'm very convinced about the waste water side, but the other two parts are undeniably true, and more than sufficient to put an end to our victory over infectious bacteria.
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Re: Antibiotic resistance: World on cusp of 'post-antibiotic

Postby vox_mundi » Sat 21 Nov 2015, 14:04:08

$this->bbcode_second_pass_quote('AgentR11', '.'). I don't know that I'm very convinced about the waste water side, but the other two parts are undeniably true, and more than sufficient to put an end to our victory over infectious bacteria.

Unfortunately, Physician over-prescription and wastewater are part of the list.

Add untreated sewage from developing countries and you have a global witches stew.

Urban wastewater treatment plants as hotspots for antibiotic resistant bacteria and genes spread into the environment: a review.
Populations of antibiotic-resistant coliform bacteria change rapidly in a wastewater effluent dominated stream.
How Can Rivers And Streams Be Sources Of Antibiotic Resistant Bacteria?
Wastewater a source of antibiotic-resistant bacteria: study
Antibiotic Resistance Associated With Wastewater Treatment Plants

$this->bbcode_second_pass_quote('', '.').. Hospital and the Waste Water Treatment Plant activities revealed to have the highest contribution to the spread of multidrug resistant bacteria in the study area.

And although wastewater treatment plants cut the number of bacteria overall, the treatment process boosts the proportion of bacteria resistant to some antibiotics, the research found.

The presence of antibiotics in sewage selects for resistance markers that are able to spread through the microbial community and as a result, antibiotic-resistant bacteria can potentially disseminate their resistance genes widely among members of the endogenous microbial community.

The sludge products of urban and rural wastewater treatment plants are increasingly used to fertilize agricultural crops, dispersing unknown amounts of resistance genes and antibiotics that withstand standard sewage treatment. (... would you like some E. coli O157:H7 with that fresh picked spinach?)

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Superbugs resistant to antibiotics

Postby onlooker » Mon 07 Dec 2015, 17:16:54

http://news.health.com/2015/12/04/phant ... ook_health
This link is to one particular one dubbed the "Phantom Menace" because it is not easily detected. This is part of the ongoing microscopic war that mankind is waging with bacteria and viruses. One particular sentence caught my eye
$this->bbcode_second_pass_quote('', 'T')his is a tricky drug-resistant bacteria, and it isn’t easily found,” CDC Director Thomas Frieden told the Post. “What we’re seeing is an assault by the microbes on the last bastion of antibiotics.”
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Re: Superbugs resistant to antibiotics

Postby onlooker » Tue 22 Dec 2015, 19:24:48

http://www.theguardian.com/society/2015 ... tic-misuse
‘Almost too late’: fears of global superbug crisis in wake of antibiotic misuse
Antibiotic Research UK director says chances of salvaging most important drugs are 50-50 after resistant bacteria found in pigs and humans in England and WalesTuesday 22 December

“It is feared the crisis could further penetrate Europe as displaced migrants enter from a war-torn Middle East, where countries such as Syria have increasing levels of antibiotic resistance.

Dr Brown told said: “It is almost too late. We needed to start research 10 years ago and we still have no global monitoring system in place.”

“The issue is people have tried to find new antibiotics but it is totally failing – there has been no new chemical class of drug to treat gram-negative infections for more than 40 years.

“I think we have got a 50-50 chance of salvaging the most important antibiotics but we need to stop agriculture from ruining it again.”
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Re: Superbugs resistant to antibiotics

Postby Newfie » Tue 22 Dec 2015, 19:32:11

Maybe you should repost this in the "mass die off thread"?

Seems it could be related.
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Re: Superbugs resistant to antibiotics

Postby onlooker » Tue 22 Dec 2015, 19:40:53

True Newfie, our most formidable foe those microscopic critters are making a comeback in a big way and appear poised to take the guise of the Overshoot Predator.
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