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THE Diabetes Thread (merged)

Discussions related to the physiological and psychological effects of peak oil on our members and future generations.

Re: Insulin after the crash

Unread postby Lighthouse » Fri 22 Dec 2006, 03:16:42

My 15 year old daughter has the same problem. Type I means in simple terms that the body (beta cells in pancreas) has stopped to produce Insulin. Type II means in simple terms the body can't use the Insulin it produces and is mainly lifestyle related.

With Type I (again in simple terms) your white blood cells attack the beta cells. No-one know for sure why that happens, some research points to a viral infection, which cause malfunction of the immune system to attack the Insulin producing beta cells in the pancreas. I think there is no proof that it is genetic. But as a matter of fact we don't know for sure what causes the disease.

10 years ago the doctors said "we are 10 years away from a cure"

since that we always were told "we are 10 years away from a cure"

We have researched since we learned about her disease and there are a lot of charlatans promising the blue from the sky.One recommendation was the works of Dr. Robert Young, who had some promising results but we haven't looked into it yet.
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Re: Insulin after the crash

Unread postby PolestaR » Fri 22 Dec 2006, 04:38:40

The people who think insulin will be easily available post collapse are making fun of the OP. The only ones who will have it will be the ones who stockpiled it and can store it. If there is no cure by the time of a collapse I would shoot my own daughter in the head right then and there, if you don't then you really are a masochist.

One reason why pharmas don't really reseach diabetes as much as they could is because at the moment it is recurring income for them. People need the drug, they get it from them, they keep making money. If there is a cure there goes lifetimes of profit. I seriously doubt we will be seeing a "cure" soon, unless it replaces a cheap often recurring income with a much more expensive less often one.
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Re: Insulin after the crash

Unread postby davep » Fri 22 Dec 2006, 07:15:41

I have two members of my family who are athyroidic and are dependent on thyroid pills. Does anyone have any info on this? Are pig/cow based remedies available?
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Re: Insulin after the crash

Unread postby EnergyUnlimited » Fri 22 Dec 2006, 07:34:17

$this->bbcode_second_pass_quote('PolestaR', 'T')he people who think insulin will be easily available post collapse are making fun of the OP. The only ones who will have it will be the ones who stockpiled it and can store it. If there is no cure by the time of a collapse I would shoot my own daughter in the head right then and there, if you don't then you really are a masochist.


You are overpessimistic here.
Primitive versions of insulin will be available well into a future. It is too low tech to go with smoke.
As I had already pointed, low tech versions, far below current FDA quality standards can literally be made in a basin of someone skilled in the art.
Only basic, trivial auxilary chemicals will be required in addition to pig or bovine pancreases, and those will be still available for long, long time (albeit in limited quantities).
Nevertheless, you will still have to pay for such an insulin in environment where 70% (or more) of family income will go to purchase food. Here I see your problems...
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Re: Insulin after the crash

Unread postby PolestaR » Fri 22 Dec 2006, 10:50:18

$this->bbcode_second_pass_quote('EnergyUnlimited', 'Y')ou are overpessimistic here.
Primitive versions of insulin will be available well into a future. It is too low tech to go with smoke.
As I had already pointed, low tech versions, far below current FDA quality standards can literally be made in a basin of someone skilled in the art.
Only basic, trivial auxilary chemicals will be required in addition to pig or bovine pancreases, and those will be still available for long, long time (albeit in limited quantities).
Nevertheless, you will still have to pay for such an insulin in environment where 70% (or more) of family income will go to purchase food. Here I see your problems...


It's easy to think I'm being pessimistic , after all I just mentioned shooting someone in the head. That to most people sort of puts a lot of dots on their "warning" radar.

But to think that the centralized way it's done now can be decentralized is a bit ludicrous. Is someone going to distribute these chemists to every town of ~700 (1 in 700 or so are born with it) ready to make their batches of insulin and other needed drugs 24/7 ? Or will all the diabetics move into Soylent Brown town where they will be given drugs in one spot?

When I say collapse I don't mean an economic depression or recession so if you think I'm talking about it under those conditions you are mistaken.
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Re: Insulin after the crash

Unread postby dooberheim » Fri 22 Dec 2006, 22:46:55

$this->bbcode_second_pass_quote('EnergyUnlimited', 'I') could post you one of basic lab scale preps, if you are interested to see, how such manufacturing could possibly look like.
Only some fancy versions (say recombinant human insulin) may no longer be available


I would rather make insulin from recombinant sources (E. coli) than animal sources, as the patient is less likely to develop an allergy to it. Once one has the appropriately transformed bacteria, one can grow bathtubs full of it, using basic animal products (milk and meat) and purify the insulin using water based, regeneratable technology. It's not tough at all - I've expressed many proteins in my work, and have often thought of how I could do this without all the oil based materials currently used.

Maybe a plasmid bank, like the seed bank they are starting in Norway?

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Re: Insulin after the crash

Unread postby Lighthouse » Sat 23 Dec 2006, 03:18:14

$this->bbcode_second_pass_quote('PolestaR', 'I')t's easy to think I'm being pessimistic , after all I just mentioned shooting someone in the head. That to most people sort of puts a lot of dots on their "warning" radar...


As usual PolestaR you are loading your gun to fast. There are always solutions, we just have to find them ...
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Re: Insulin after the crash

Unread postby PolestaR » Sat 23 Dec 2006, 03:57:09

$this->bbcode_second_pass_quote('Lighthouse', '')$this->bbcode_second_pass_quote('PolestaR', 'I')t's easy to think I'm being pessimistic , after all I just mentioned shooting someone in the head. That to most people sort of puts a lot of dots on their "warning" radar...


As usual PolestaR you are loading your gun to fast. There are always solutions, we just have to find them ...


Which is why I said if there wasn't a cure BY the time of a collapse. People will be struggling to eat enough food and drink enough clean water yet luxury items like insulin will still be made for diabetics? Please. :)
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Re: Insulin after the crash

Unread postby EnergyUnlimited » Sat 23 Dec 2006, 04:58:04

$this->bbcode_second_pass_quote('dooberheim', '
')I would rather make insulin from recombinant sources (E. coli) than animal sources, as the patient is less likely to develop an allergy to it. Once one has the appropriately transformed bacteria, one can grow bathtubs full of it, using basic animal products (milk and meat) and purify the insulin using water based, regeneratable technology. It's not tough at all - I've expressed many proteins in my work, and have often thought of how I could do this without all the oil based materials currently used.

Maybe a plasmid bank, like the seed bank they are starting in Norway?

DK


You can make recombinat insulin, as long as you have appropriate E. Coli culture available.
If you cannot get a hold of such culture, you will fail to make recombinant insulin.
I assume, that under any societal collapse scenario it will be far easier to get hold of pig pancreases, than to get hold of genetically engineered bacterial cultures.

BTW, if you had managed to *save* a sample of such culture through collapse, you could make quite decent living later...
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Re: Insulin after the crash

Unread postby manu » Tue 26 Dec 2006, 03:24:40

Of the twenty types of diabetis, fourteen are cureable according to ayurveda. But it is a lifestyle chance. Diet and exercise have to be there with the herbal medicines.
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Re: Insulin after the crash

Unread postby EnergySpin » Tue 26 Dec 2006, 12:19:28

$this->bbcode_second_pass_quote('EnergyUnlimited', '
')I assume, that under any societal collapse scenario it will be far easier to get hold of pig pancreases, than to get hold of genetically engineered bacterial cultures.

Under any societal collapse scenario it will be impossible to process pig pancreases because a) it will be impractical to maintain the industrial pig/bovine farms (why do you think Novo Nordisk has a cow in its company logo?) b) the solvents and enzymes required to process pancreases and chemically modify the extracts require considerable chemical/biochemical expertise (the history of Novo Nordisk, or the site I reference latter will give you an idea of the amount of expertise that is required).
It will be considerably easier to continue using the GM stuff (which is what Cuba did during their artificial "severe" PO. They did not revert to animal farming ... they simply used E.coli POWER !

In any case, the history of insulin discovery and production is covered in the following site: http://www.discoveryofinsulin.com/
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Re: Insulin after the crash

Unread postby dooberheim » Sat 30 Dec 2006, 06:20:19

I'd think there will always be pigs and cows to be had. But I think recombinant technology will be too valuable to be lost. A problem is patent and proprietary concerns - I'd hope in a powering down world that plasmids and growth stocks of truly useful drugs could be saved for use in a bank and distributed to those that could use them in their communities.

Of course the chances of that happening are pretty small, but one can hope...

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Re: Insulin after the crash

Unread postby EnergyUnlimited » Sat 30 Dec 2006, 08:31:02

$this->bbcode_second_pass_quote('EnergySpin', '')$this->bbcode_second_pass_quote('EnergyUnlimited', '
')I assume, that under any societal collapse scenario it will be far easier to get hold of pig pancreases, than to get hold of genetically engineered bacterial cultures.

Under any societal collapse scenario it will be impossible to process pig pancreases because a) it will be impractical to maintain the industrial pig/bovine farms (why do you think Novo Nordisk has a cow in its company logo?) b) the solvents and enzymes required to process pancreases and chemically modify the extracts require considerable chemical/biochemical expertise (the history of Novo Nordisk, or the site I reference latter will give you an idea of the amount of expertise that is required).
It will be considerably easier to continue using the GM stuff (which is what Cuba did during their artificial "severe" PO. They did not revert to animal farming ... they simply used E.coli POWER !

In any case, the history of insulin discovery and production is covered in the following site: http://www.discoveryofinsulin.com/

Could you name any enzyme critical in extracting of insulin from pig/bovine pancreas, which is not already there?
I could not.
Do you see any chemical modification of animal (pig/bovine) insulin as critacal condition for human use? Please neglect zinc complexation or S-S coupling/decoupling here as irrelevant.
Those are done to increase stability, solubility/availability profile etc.
I do not.
Do you think, that insulin can be extracted from E. Coli without auxilary organic solvents?
I do not.
Do you think that pig cannot be farmed without Monsanto (or similar company) assistance?
I do not.
Do you think, that GM E. Coli cultures will be easy available in die-off or in post nuclear war environment?
I do not.

PS. Insulin extraction does not require high tech expertise or big pharma proprietary knowledge. You can produce it easily without their help/assistance at all. Current FDA standards would not be met under this scenario, but who know, what the standards will be applicable in pending societal collapse environment...and who will take any care or even notice of those...

I can send you a simple prep of insulin (if it is of any interest to you).
It was quite easy experiment in organic chemistry lab, when I was attending university (chemistry dept.).
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Re: Insulin after the crash

Unread postby EnergySpin » Sat 30 Dec 2006, 16:48:31

$this->bbcode_second_pass_quote('EnergyUnlimited', '')$this->bbcode_second_pass_quote('EnergySpin', '')$this->bbcode_second_pass_quote('EnergyUnlimited', '
')I assume, that under any societal collapse scenario it will be far easier to get hold of pig pancreases, than to get hold of genetically engineered bacterial cultures.

Under any societal collapse scenario it will be impossible to process pig pancreases because a) it will be impractical to maintain the industrial pig/bovine farms (why do you think Novo Nordisk has a cow in its company logo?) b) the solvents and enzymes required to process pancreases and chemically modify the extracts require considerable chemical/biochemical expertise (the history of Novo Nordisk, or the site I reference latter will give you an idea of the amount of expertise that is required).
It will be considerably easier to continue using the GM stuff (which is what Cuba did during their artificial "severe" PO. They did not revert to animal farming ... they simply used E.coli POWER !

In any case, the history of insulin discovery and production is covered in the following site: http://www.discoveryofinsulin.com/

Could you name any enzyme critical in extracting of insulin from pig/bovine pancreas, which is not already there?
I could not.
Do you see any chemical modification of animal (pig/bovine) insulin as critacal condition for human use? Please neglect zinc complexation or S-S coupling/decoupling here as irrelevant.
Those are done to increase stability, solubility/availability profile etc.
I do not.
Do you think, that insulin can be extracted from E. Coli without auxilary organic solvents?
I do not.
Do you think that pig cannot be farmed without Monsanto (or similar company) assistance?
I do not.
Do you think, that GM E. Coli cultures will be easy available in die-off or in post nuclear war environment?
I do not.

PS. Insulin extraction does not require high tech expertise or big pharma proprietary knowledge. You can produce it easily without their help/assistance at all. Current FDA standards would not be met under this scenario, but who know, what the standards will be applicable in pending societal collapse environment...and who will take any care or even notice of those...

I can send you a simple prep of insulin (if it is of any interest to you).
It was quite easy experiment in organic chemistry lab, when I was attending university (chemistry dept.).

How do Cubans get their insulin? If animal farming was much easier than turning to E.coli they would have done the former rather than the latter after their "peak oil". Trypsin was an important breakthrough in the industrial manufacturing of insulin from animal organ extracts .... digests the pancreas pretty efficiently. I have no interest in non GM modified insulin ... the pig/cow variety were impure and they lead to the formations of auto-antibodies which was a bitch to deal with in the old days.
And I would not dismiss the modifications you referenced ... there was a reason why they were done, and self-stability was only one of them.
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Re: Insulin after the crash

Unread postby smallpoxgirl » Sat 30 Dec 2006, 19:54:30

Diabetes:

Type I diabetes is an autoimmune disease. The bodies immune system, for unknown reasons, one day decides to attack and kill all the insulin producing cells in your pancreas. There is no effective treatment other than injecting insulin into the body to replace the insulin that's not being made. Type I virtually always happens in childhood.

Type II diabetes is a metabolic problem. People who are obese and eat bad food need higher insulin levels to keep their blood glucose regulated. Over time the pancreas basically wears out. It can't keep up with the demand. Type II can be treated with a variety of things: There are oral meds. Exercise and weight reduction are huge helps. In the later stages, Type II diabetics may end up needing to inject insulin. Type II diabetes use to be reffered to as "adult onset". In the era of x-box and soda pop, more kids these days are getting Type II than Type I.

The reality of third world diabetes is that Type II almost never happens because people are physically active and don't over eat as badly. Type I diabetics in the third world, I suspect, die pretty quickly. The obvious problem with making your own insulin is that pancreas is also a major source of digestive enzymes. Insulin has to be injected. You go shooting yourself full of digestive enzymes and you are going to be a hurting puppy in short order. Unless you happen to be a PhD biochemist, I seriously doubt that any of you are going to be making your own insulin.

Someone asked about thyroid insufficiency:

That's much easier because thyroid hormone can be taken orally. Armor Thyroid is a preparation that a lot of people use even now for thyroid insufficiency. It's basically just ground up cow thyroid glands in weighed out quantities in a pill.
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Re: Insulin after the crash

Unread postby EnergyUnlimited » Sun 31 Dec 2006, 05:32:30

$this->bbcode_second_pass_quote('smallpoxgirl', 'T')he reality of third world diabetes is that Type II almost never happens because people are physically active and don't over eat as badly.

I think, it is a large problem in Middle East countries, but I may be wrong. When I was working in UK pharma/chemical company, we had few Arabs there and they were all diagnosed with Type II.
This of course can be coincidental.
$this->bbcode_second_pass_quote('', 'T')ype I diabetics in the third world, I suspect, die pretty quickly.

You are right here.
$this->bbcode_second_pass_quote('', 'T')he obvious problem with making your own insulin is that pancreas is also a major source of digestive enzymes. Insulin has to be injected. You go shooting yourself full of digestive enzymes and you are going to be a hurting puppy in short order. Unless you happen to be a PhD biochemist, I seriously doubt that any of you are going to be making your own insulin.

It is obvious, that guy trained in accountancy (and nothing else) will fail to make insulin, regardless how much effort he makes.
However for a skilled organic chemist (does not need to be a biochemist at all, neither PhD is essential here) the task may prove to be not very difficult one (as long as basic auxilary chemicals and solvents are available).
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Re: Insulin after the crash

Unread postby EnergyUnlimited » Sun 31 Dec 2006, 06:01:13

$this->bbcode_second_pass_quote('EnergySpin', '
')How do Cubans get their insulin? If animal farming was much easier than turning to E.coli they would have done the former rather than the latter after their "peak oil".

You are talking about PO environment and I am talking about societal collapse environment.
Those are different things.
I am well aware, that GM E. Coli insulin is superior to porcine version, nevertheless you can only manufacture it, if GM cultures are available.
Under societal collapse scenario it may prove to be extremely difficult (if not impossible) to produce GM microorganisms from scratch.
If you are not in possession of saved sample of such E. Coli culture, you may well forget that idea.
$this->bbcode_second_pass_quote('', 'T')rypsin was an important breakthrough in the industrial manufacturing of insulin from animal organ extracts .... digests the pancreas pretty efficiently.

1. Important, but not critical.
2. Trypsin is present in pancreas (presumably it is handy to add a bit more of it).
$this->bbcode_second_pass_quote('', 'I') have no interest in non GM modified insulin ... the pig/cow variety were impure and they lead to the formations of auto-antibodies which was a bitch to deal with in the old days.

Neither do I. Noone in my family suffers of any diabetes.
Your concerns regarding bovine/porcine versions are well founded.
However, if you don't have what you like, learn to like what you have...
$this->bbcode_second_pass_quote('', 'A')nd I would not dismiss the modifications you referenced ... there was a reason why they were done, and self-stability was only one of them.

As I had said, they are handy but not critical.
I assume, that person capable to isolate insulin in the first place, would be also capable to make these modifications, if deemed necessary. Only small amounts of few additional chemicals would be required.
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Re: Insulin after the crash

Unread postby smallpoxgirl » Sun 31 Dec 2006, 07:14:49

$this->bbcode_second_pass_quote('EnergyUnlimited', 'I')t is obvious, that guy trained in accountancy (and nothing else) will fail to make insulin, regardless how much effort he makes.
However for a skilled organic chemist (does not need to be a biochemist at all, neither PhD is essential here) the task may prove to be not very difficult one (as long as basic auxilary chemicals and solvents are available).
Everything is easy, if you know, how to do it...
It would take an experienced chemist and a lab full of chemicals to pull off something like that. My undergrad is in chemistry and I've done a fair bit of bench biochemistry. With a well equiped lab and enough time, I could probably pull off the extraction they're talking about, but it would be no mean feat. Then you've got to calibrate the insulin you've extracted. What they described in the paper was administering it to pancreatectomized animals an checking their blood glucose to standardize your prep. Do you think you can perform a Whipple procedure on a dog and get it to live? I'm not sure I could. Surgeons have a saying "If god had intended the pancreas to be operated on, he would have made it easier to get to." A Whipple procedure in a modern hospital probably has a 30% mortality rate. You're probably going to have to do a dog a week to have one around to standardize your insulin extractions with. By the way, how you are gonna measure the blood glucoses? That's going to be a serious problem of it's own once the glucometer strips run out. Then you add in the problem of adolescent diabetics are very difficult to keep controlled under the best of circumstances because they don't want to be taking their sugars and giving themselves insulin all the time. I think the reality is that it is simply not reasonable to expect that kind of resources are going to be available to take care of one kid who under the best of cricumstances is going to have a significantly foreshortened lifespan anyway.
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Diabetes

Unread postby joelcolorado » Wed 25 Jun 2008, 08:55:03

America will lose a huge amount of ppl right up front in the melt down due to our lack of health concerns. There is a new case of diabetes diagnosed every 4 seconds. Without medicine which is expensive, they will all die a slow death.

And whats sad, if ppl walked more, ate right an watched their lifestyle choices, many would never develop diabetes. What a shame. They all want a pill to make it better instead of losing wt. etc.
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Re: Diabetes

Unread postby Pretorian » Wed 25 Jun 2008, 09:20:02

Doesn't one has to be predisposed to diabetes to develop it?
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