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THE Diabetes Thread (merged)

Discussions related to the physiological and psychological effects of peak oil on our members and future generations.

Re: THE Diabetes Thread (merged)

Postby dissident » Wed 27 Nov 2013, 13:32:04

http://articles.mercola.com/sites/artic ... sugar.aspx

Both my parents are Type II diabetics (one is not fully developed and can keep his condition under control through diet and supplements). Cinnamon is very effective for blood sugar control. Try it before you go on assorted pharmaceutical crap which has major side effects (e.g. metformin damages the liver, see http://care.diabetesjournals.org/content/35/3/e21.full and ignore the BS about low incidence rate, it's still damage even if you don't have to be hospitalized for it and things don't get better with age!)
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Re: THE Diabetes Thread (merged)

Postby PeakOiler » Wed 27 Nov 2013, 15:12:30

I get my blood tested about 3-4 times a year. My last hA1C was 5.5. :) Seven-day glucose average is ~108 mg/dL.

In fact, all the other analytes (cholesterol, lipid panel, salts, etc.) were all in the normal ranges.

The doctors told me don't change a thing in your drug, supplements, and current diet.

I'm still trying to gain about another 8-10 pounds. (Hopefully muscle, lol). I've got some tree transplanting to do this next spring!
There’s a strange irony related to this subject [oil and gas extraction] that the better you do the job at exploiting this oil and gas, the sooner it is gone.

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Re: THE Diabetes Thread (merged)

Postby Timo » Wed 27 Nov 2013, 16:23:18

Not to belittle anyone's personal experiences with diabetes (trust me, i'm not), i'm relatively new to the entire disease, and have been forced to educate myself on its causes and treatements. As far as that goes, the volume of information regarding this desease just goes on and on and on and on and......... I don't have diabetes, but 6 months ago, my Newfie (sorry Newfie) was diagnosed with diabetes, which in dogs, is more similar to Type 2 in people. Being a Newfoundland, she's a big girl, and topped out at 115 lbs. I've never had a dog that big before, and her breed is naturally that big, so i never thought anything about her weight until she suddenly could not walk. Anyway, several years ago, she also had imunothrombocytopenia (i hope i spelled that right), or ITP for short. That disease is when the body's own immune system attacks the platelets in the blood. Normal platelet levels for her were suppose to be in the 400,000 range, and she was down to the single digits. So, we had to dose her up with Cyclosporine for 9 months to shut her immune system completely down. Those meds aren't cheap!!! But, that did solve her problem at that time. Now, for something completely different: Diabetes!!! And, a natural side-effect of diabetes is neuropathy, which, after more research, can be successfully minimized with a vitamin B-12 supplement, which ironically has cyanide. Still, 21 units of insulin, and another 20 units of Cyanobolomine, 2X day, coupled with 650 calories each time, and she's almost back to complete normal! And under 100 lbs, too. The only real difference in her now is the gradual appearance of cataracts. Does anyone have any personal experience with that aspect of diabetes?
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Re: THE Diabetes Thread (merged)

Postby Tanada » Thu 28 Nov 2013, 15:11:08

I don't know if it is relevant to you or not but in the wild wolves, the Dog ancestor, eat a predominantly meat and fat diet while the vast majority of modern 'dog food' would be perfectly acceptable feed for livestock. My own dog is an arctic breed and for the last 1,000 years or so his ancestors worked as hunting dogs in Scandinavia where their diet was rich in fish and scrap meat/fat from game animals and livestock. As a result my breed guide has me feeding him either fish or fish oil supplements once per week. I am not a vet but omega fish oil supplements are a lot cheaper than trips to the vet and all my dog has ever been in for is regular shots and antibiotics from when he gouged his throat while chewing things better left unchewed. Puppies do the darndest things.

Anyhow the Omega three capsules from my vet are called Aller G-3, before I got these I used just plain old Fish-oil capsules from the super market. The ones from the store are about half the cost so I will probably go back to them once these are used up.

Best of luck!
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Re: THE Diabetes Thread (merged)

Postby Tanada » Tue 03 Dec 2013, 13:03:26

Something I stumbled across that I have verified via the US Federal Government research on worker health and safety in companies using Acetone. Despite what most biochemistry textbooks and lectures say the human body, specifically the liver, is quite adept at converting acetone into glucose. This is important for anyone on a low carb diet but especially important for type 1 diabetics because it can lead to unexpected blood sugar levels when your body is producing large numbers of ketone bodies.

http://blog.cholesterol-and-health.com/ ... fatty.html
$this->bbcode_second_pass_quote('', 'I')n 1986, researchers administered radioactively labeled acetone to rats and examined the radioactive carbon "fingerprint" on the glucose molecules formed from it to provide additional evidence that acetone followed pathways leading to pyruvate that would indeed lead to a net synthesis of new glucose (5). That same year, the Philadelphia group used a similar approach to show that acetone was following similar pathways in humans with diabetic ketoacidosis (6). They estimated that in such patients at least ten percent of newly synthesized glucose may come from acetone.

Blood levels of acetone also rise appreciably in adults on the Atkins diet (7) and in epileptic children following a ketogenic diet (8), suggesting that it may be a normal state of affairs for humans to convert fatty acids to glucose when consuming a diet low in carbohydrate and high in fat.

For comparison, I compiled the blood levels of acetone reached in humans under various conditions in the following table:$

Image
$this->bbcode_second_pass_quote('', 'I')n July of 2011, a German research group revisited the question of converting fatty acids to carbohydrate by publishing a computational analysis of the most up-to-date information about human biochemistry available (9). These authors identified 22 pathways by which acetone could be converted to pyruvate that they considered likely to be important, and concluded that these pathways would be less cost-efficient than making glucose from amino acids or glycerol, but are nevertheless biochemically feasible and likely serve as supplementary modes of glucose production.

Lo and behold, we have three decades of evidence suggesting that the Land of Ketogenesis is graced with its own Candy Factory. Sure, the desserts conjured therein may be sold at higher prices than those made in the Candy Factory just off exit eight of the TCA cycle, but when the traffic is heavy there, what else are we to do? Such is the law of supply and demand.

Insulin Regulates Gluconeogenesis From Fatty Acids


The EPA report on acetone metabolism can be found http://www.epa.gov/iris/toxreviews/0128tr.pdf
Pay special attention to page 25 of the pdf, it diagrams the acetone metabolism pathways in excruciating detail for this interested in biochemistry.
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Re: THE Diabetes Thread (merged)

Postby Timo » Tue 03 Dec 2013, 13:24:22

Thanks, Tanada. I'll ask my vet about Omega-3s and fish oil. Her diet right now is prescription diabetic dog food, and prior to that, it was strictly Science Diet large breed dry. Science Diet is supposed to be the best in the biz, so who knows what happened to cause her diabetes?! Life isn't easy for anyone, i suppose. Humans, or otherwise.
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Re: THE Diabetes Thread (merged)

Postby Timo » Tue 03 Dec 2013, 14:43:56

WOW! I'm a 7 (?) year practicing vegetarian, and for the past 4 years, i've just attrbuted my dizziness and disequilibrium to my brain injury. Only partially kidding, but do you suppose there is a possible link between my diet and ongoing balance problems? Part of me considers that question to be a joke because i rationally, really do not think there's any correlation, but the other part of me has learned not to discount any possible cause and effect relationship, post TBI.
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Re: THE Diabetes Thread (merged)

Postby Pops » Tue 03 Dec 2013, 15:51:09

Timo, I'm repeating myself but the biggest everyday problem I had after developing diabetes was afternoon brain fog. Some of the big bacon fat advocates on one of the diabetes boards suggested that since I was eating a low-but-not-no-carb diet I was possibly moving in and out of ketosis causing my brain to have a hard time adjusting to one or the other. The brain can operate on perhaps 50% ketones just fine but it takes a period for it to adjust.

Here is the first article that popped up:
http://www.psychologytoday.com/blog/evo ... in-ketones
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Re: THE Diabetes Thread (merged)

Postby Subjectivist » Tue 03 Dec 2013, 15:55:58

$this->bbcode_second_pass_quote('pstarr', 'T')anada, why is acetone-glucose conversion interesting to those of us who don't work with industrial solvents? I know many on this site are shut-ins, spending a lot of time with plastic-model cement, constantly updating the command deck on their Starship Enterprise toys, but what about those who choose not to sneak sniffs of the cement? Is this a paleo thing? Did our ancestors huff? LOL


Recently I have been trying out nutritional ketosis and as such have seen a lot of nattering online about how low carb strips your muscle glycogen stores. This sounds like your liver also grabs the acetone my biochem textbook calls a useless waste product and converts it into glucose. The more I look into this stuff the more often I find that what I was taught at the university is not just suspect, it is down right wrong!

My doctor labled me pre-diabetic last fall and wanted to put me on medication. I elminated most sweets and wheat from my diet and now have normal blood sugar. The doctor is convinced it was his advise to excercise more that fixed me up. Dr. Lustig has some anti sugar lectures on youtube that really inspired me to kick the sweet habit for the most part.

Now this stuff is saying nutritional ketosis can raise my blood sugar. I will have to keep hat in mind as I am trying to avoid diabetes.
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Re: THE Diabetes Thread (merged)

Postby Tanada » Tue 03 Dec 2013, 17:08:36

$this->bbcode_second_pass_quote('pstarr', 'T')anada, why is acetone-glucose conversion interesting to those of us who don't work with industrial solvents? I know many on this site are shut-ins, spending a lot of time with plastic-model cement, constantly updating the command deck on their Starship Enterprise toys, but what about those who choose not to sneak sniffs of the cement? Is this a paleo thing? Did our ancestors huff? LOL



Anyone who goes low carb/no carb produces a fair amount of acetone in their blood from the spontaneous decarboxylation of acetoacetate forming CO2 and acetone. Based on the EPA study I linked above a minimum of 30% and a maximum of 85% of that spontaneous acetone in the blood is converted into glucose by the liver. The rest of it is excreted in breath and urine, but the more acetoacetate your liver makes the more acetone your body gets from the breakdown reaction and the more glucose your body makes from fat stores. Most paleo/primal people are low starch, but of course some are not. I keep flirting in and out of ketosis because for example I cheated Thursday/Friday/Saturday eating lots of carb filled Thanksgiving food. I had committed to trying ketosis but unless I am full on very low carb its a tough place for me to get into and stay in. I managed to hold it for about two weeks before all that holiday food got me off track.
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Re: THE Diabetes Thread (merged)

Postby Subjectivist » Mon 16 Dec 2013, 09:24:35

Video interview with Dr. Georgia Ede about nutritional ketosis and I learned that I might be eating too much protien causing my body to convert the excess into blood glucose. She also recomends counting calories and not going crazy on the all fat diet like some people advocate, 80% fat but a logical calorie count for your body.

http://m.youtube.com/watch?v=Yv9dTpoLbe0

http://diagnosisdiet.com/blog/

$this->bbcode_second_pass_quote('', 'C')arbohydrate sensitivity tends to worsen over the years, as the body’s system for handling sweets and starches gradually wears out. Type 2 diabetes is essentially the final stage of this process–it is your body’s way of telling you that it simply cannot process carbohydrate anymore. If you already have diabetes, the fat lady has sung. But never fear. There are simple things you can do to stop and even reverse this downward spiral of metabolic madness.

First of all, it would be helpful to know whether or not you are on this path already—how do you know if you are at risk for obesity, type 2 diabetes, high blood pressure, heart disease, and all of the other chronic health problems that come along with carbohydrate sensitivity? Take this QUIZ to see where you are on the spectrum of carbohydrate sensitivity, and then follow the links for advice about how you can change your diet to change the course of your future.
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Re: THE Diabetes Thread (merged)

Postby Pops » Mon 16 Dec 2013, 09:46:58

FWIW, I figure carbs at 100%, protein at 50% and even some small amount of fat as eventually turning to glucose (the "glyceride" of mono-, di-, tri-gliceride is sugar alcohol). Protein takes several hours to raise blood sugar and fat even longer so they provide energy without the BS spike.

A1c measures long term average blood sugar but of course an average in a range of 30-300mg/dl might be the same as one in a 70-100 range but be much less healthy.
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Re: THE Diabetes Thread (merged)

Postby Subjectivist » Sat 11 Jan 2014, 16:15:21

FDA approved Dapagloflozin Wednesday but I was too weather distracted to notice.
$this->bbcode_second_pass_quote('', 'T')he Food and Drug Administration on Wednesday approved U.S. marketing of the drug dapagliflozin, the second of a new class of medications that aim to improve glycemic control in patients with Type 2 diabetes. The drug will be marketed under the name Farxiga.
Dapagliflozin is a sodium-glucose co-transporter 2 (SGLT2) inhibitor, a drug that blocks the reabsorption of glucose by the kidney, increases the excretion of glucose in urine and lowers glucose levels in the blood.
It will join -- and is likely to be prescribed in conjunction with -- a wide range of diabetes medications, including metformin, pioglitazone, glimepiride, sitagliptin and insulin. Many patients with Type 2 diabetes are at risk for complications such as cardiovascular disease and damage to peripheral nerves and small blood vessels; existing diabetes drugs and changes in diet and exercise do not drop levels of circulating blood sugar enough.
Dapagliflozin's approval follows that of canagliflozin, the first in this class of medications to receive the FDA's blessing, last March. Four more drugs in this new category of Type 2 diabetes medications are expected to go before the FDA in the coming years.


http://www.latimes.com/science/sciencen ... z2q7fi7DDA
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Re: THE Diabetes Thread (merged)

Postby dissident » Sat 11 Jan 2014, 17:43:46

To dismiss Atkin's based on "it will all turn to glucose anyway" is just too simplistic. The Atkin's diet allows people with insulin resistance to get off the insulin-hunger yoyo. It is not some prescription to replace every carb calorie with a protein/fat calorie. So, to leading order, it allows a reduction of calorie consumption. The enormous insulin spike after any meal in the case of insulin resistant individuals results in over-reduction of blood sugar levels shortly after the meal. Low blood sugar levels trigger hunger even though there is no actual nutrient and energy deficiency. High insulin levels also trigger over-production and over-storage of fat (although this is also complicated by the behaviour of fat storage cells in response to high insulin levels and not all people with insulin resistance go on to become obese). Insulin is the fat hormone.

Any glucose production from ketones generated by this sort of diet is a side show. This diet does not have a large positive impact on people without insulin resistance. It is typical to talk about all people as having the same dietary needs. This is BS peddled in the MSM by hack journalists.
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Re: THE Diabetes Thread (merged)

Postby Tanada » Mon 20 Jan 2014, 09:46:54

The best thing about limiting carbs has been getting off the hunger yo-yo. When I was a teen I hardly ever got hungry as in my tummy is growling. From my early 20's through my 30's and into my first half of the 40's I tried all kinds of diets and they always left me hungry and caused me to give up after a few pounds. Since I went low carb 52 weeks ago I have lost 40 pounds and I am rarely hungry, and when I get hungry I eat some solid and low carb food and the hunger goes away for 5 or 6 hours. I am not diabetic but my spouse is. After adopting the eat meals with no snacks in between and try and have 12 or more hours between at least two of your meals my diabetic spouse has lost about 10 pounds and has been able to stop taking two medications to control diabetes. The hope is as the body adjusts to the new weight even more meds will be eliminated, but at this point the health is improving and the weight is coming off without painful effort and constant hunger.

This video is what caused my spouse to adopt this new plan, it is for Type 2's, not Type 1's but if it helps you too more power too you!

http://www.youtube.com/watch?v=4oZ4UqtbB_g
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Re: Do You Sip Your Own Kool Aide?

Postby Subjectivist » Wed 09 Apr 2014, 09:56:27

$this->bbcode_second_pass_quote('Pops', 'I')'d take a link, Sub. Thanks


http://www.prospecbio.com/Insulin_Porcine_2_21/

http://www.cellapplications.com/product ... hp?id=2195

The first one is for use by diabetics, the second is a supplier for laboratory experiments but is useable the same way. The longer you keep it frozen the longer you can keep it, but insulin is a protein just like meat and repeated freeze thaw cycles cause it to denature. If you buy in bulk you will want to divide it into divide it into smaller sterile containers so you only have to thaw a few doses worth at a time.

Hope this info is helpful. If you are alergic to either beef or pork obviously you need to use the other one, before human analog insulin in the USA the Rx was a mix of porcine (pig) and bovine (cattle) insulin available in either powder or premade liquid form.

For making your own from animal pancreas look for a book called How Its Made from the 1960's. I never got around to buying it but I am told it gives detailed instructions on how they extracted insulin from slaughtered animals.

For the plasma emergency method you just need to extract a blood sample from the volunteer and centerfuge it until the RBC and WBC form distinct layers in the bottom of the sample, then carefully extract the plasma off the top. Making a simple centerfuge from a bicycle is easy, you turn it in its side and put the vile securely between the spokes and hand crank it as fast as you can for several minutes.
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