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PeakOil is You

PeakOil is You

THE Pandemic Thread (merged)

Discussions related to the physiological and psychological effects of peak oil on our members and future generations.

Unread postby OilsNotWell » Mon 09 May 2005, 23:34:23

There is an EXTENSIVE influenza news board here at www.CurEvents.com :


CurEvents "Flu Clinic"

Many informative posts there.....

If you wish to pursue this issue in far more detail with lots of like-minded persons, that seems a good place...

I'll post a few of the major stuff here...

Here's an interesting exchange, and I'll post it in its entirety:

$this->bbcode_second_pass_quote('', '[')quote author=LMonty911
I dont expect the coming pandemic to "Go Away" like SARS did- yet, i am already hearing that it "will probably fizzle just like SARS" from the few docs I've talked to.
Quote:



I don't think SARS "went away" so much as it was strangled to death by effective communication and serious quarantines (once people got in gear). At one point the affected countries had thermometer checks at all airports, Chinese villagers were blockading roads to their area with pitchforks, and Beijing effectively shut down for a few days after constructing a special purpose hospital just for SARS patients in the span of about 7 days, if I recall correctly. I'll never forget listening to the NPR reporter as I was driving into work:

"I'm in Beijing looking down mainstreet. It looks deserted. I see a policecar... and a hearse."

Sri Lanka enforced mandatory quarantines and everyone in a particular Hong Kong hotel was packed off to a holiday camp.

My feeling is that if something reasonably contagious like SARS (which had the occasional 'super-spreader' as well) could be beaten in high population areas like Hong Kong, then a lethal flu could be handled as well. The only really worrisome part is the multitude of natural resovoirs that H5N1 seems to work with, whereas SARS didn't seem to be partial to small flying critters.

Anyway, if it does make a serious play, don't underestimate the power of communication once it gets into gear. Myself, I'll be paying attention, but my threshold for alarm (as a layperson) is when something is serious enough to close a hospital on my continent. First thing I noticed about SARS was when it took down the Vietnam hospital and it was closed for 'cleaning'

Second thing was when it killed the infectious disease expert WHO sent to study it. Now there's a red flag for you. But, it was beaten back when people got serious about it.

People like to live. Once it hits home that something is a serious threat, it will be dealt with. Would the 1918 pandemic have claimed as many people as it did if the original resurfaced now? The virus gets the bonus of jet-speed travel, but the humans have the advantage of light speed communication. Its a big one. In 1918 you and I wouldn't have a CLUE what was going in Vietnam, or pretty much anywhere else outside of our backyard.

My 2 cents.


and the reply:

$this->bbcode_second_pass_quote('', 'g')hostly_poet's inquiry: > Would the 1918 pandemic have claimed as many people as it did if the original resurfaced now?

>The virus gets the bonus of jet-speed travel, but the humans have the advantage of light speed communication. Its a big one. In 1918 you and I wouldn't have a CLUE what was going in Vietnam, or pretty much anywhere else outside of our backyard.

GR's stab at a reply: The feeder lines into the first world are the airlines. If you can swear to me that these are shut down from day one, out of Vietnam, that would stopper the disease for a while, but only a while.

The virus is endemic. It is assumed it will "sprout" in many locale's at the same time. (not at first, but shortly after infection starts) What I know to be true, as we're seeing in Marburg-country, people will flee the virus; every wealthy family will make an effort to leave or send a portion of their family out of the country; if the airline is shut to them into HK, they'll fly to Thailand and wherever, and change planes. They're wealthy, smart, educated, and have a very pressing need to "move". The story in China is not the same story as in the West. We're not autocracies.

It's your premise that people will be frozen in place; that's an assumption with differing recent facts supporting both arguments. As your position is an assumption, it's a matter of where you place your bets. I'll not bet along with you. Your bet has a sudden death show of hands. It will be a hand that will be played without chips, and with your own wits as your betting pot.

Here, many are taking a more conservative position. It's a wait and show me, but meanwhile, I'll review and prepare my options. If they're wrong, they hold Tamiflu or food, or cleaning supplies for a lifetime, or emergency plans.

The recent Contra Costs County, California emergency response rehearsal includes what they believe to be true, different from what you think. They believe that air travel will bring a few people infected into their County (about say 1 million people, on the high side). They expect the flu to spread in two ways: first, the carriers will become sick and their closest relatives will become sick, and some on the airplane will become sick (the studies show between 2 and 8 rows of people, though not all, if exposed for a long time, here about 15 - 20 hours, will get sick). Because the flu is transmitted for 1 to 3 days prior to signs of illness appearing, those who received their loading doses are also transmitters.

But you know all this. The point is that unlike China, where streets are empty, even the thought of quarantine, and using the words of one WHO person, draconian quarantine, may go into effect, but not without time passing and in that time, the disease will spread.

But, to help us all, in June, Nature Magazine will publish the results of the US Government from its computer modelling program on this very topic.

If you'd like to know whether you're on the right track, we've posted here the fact that a participating statistician in that study is now urging that the governments of the world, via WHO, use Tamiflu blankets on every outbreak in Asia, quickly, with all bets off if the virus breaks out in a large city, because he sees the disease unstoppable if it gets out from under those blankets. I tend to go with the statistician on this; his MIDAS study is a bit more costly and complete than yours or mine.

I personally don't think it wise to follow your approach; but as you're informed and an adult, your opinion is 100% valid for you.

As a counter comment, I think it wise for everyone here who's interested to read the many, many posts on pandemic preparation over in the www.curevents.com Flu Clinic newsgroup, a sub-group of The Laboratory. That's the primary theme in that group at this time, summed up as "personal survival and local assistance"

After the Nature report in June, please post your thoughts here at that time, when you've seen some detailed stat's on viral transmission.
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Unread postby OilsNotWell » Tue 10 May 2005, 00:19:52

Trying to keep things balanced (read: not FREAK people too much), here's some folksy, but good tips:

$this->bbcode_second_pass_quote('', '1')2 Tips to Prevent Cold and Flu the "Natural" Way

WebMD Medical Reference
Since there are no known cures for colds and flu, prevention must be your goal. A proactive approach to warding off colds and flu is apt to make your whole life healthier. The most effective way to prevent flu, frankly, is to get the flu shot. It may not be natural, but it works better than anything else. But there are other strategies you can employ as well. WebMD went to Charles B. Inlander, president of The People's Medical Society, for suggestions you may want to try:

#1 Wash Your Hands

Most cold and flu viruses are spread by direct contact. Someone who has the flu sneezes onto their hand, and then touches the telephone, the keyboard, a kitchen glass. The germs can live for hours -- in some cases weeks -- only to be picked up by the next person who touches the same object. So wash your hands often. If no sink is available, rub your hands together very hard for a minute or so. That also helps break up most of the cold germs.

#2 Don't Cover Your Sneezes and Coughs With Your Hands

Because germs and viruses cling to your bare hands, muffling coughs and sneezes with your hands results in passing along your germs to others. When you feel a sneeze or cough coming, use a tissue, then throw it away immediately. If you don't have a tissue, turn your head away from people near you and cough into the air.

^ Back to top

#3 Don't Touch Your Face

Cold and flu viruses enter your body through the eyes, nose, or mouth. Touching their faces is the major way children catch colds, and a key way they pass colds on to their parents.

^ Back to top

#4 Drink Plenty of Fluids

Water flushes your system, washing out the poisons as it rehydrates you. A typical, healthy adult needs eight 8-ounce glasses of fluids each day. How can you tell if you're getting enough liquid? If the color of your urine runs close to clear, you're getting enough. If it's deep yellow, you need more fluids.

^ Back to top

#5 Take a Sauna

Researchers aren't clear about the exact role saunas play in prevention, but one 1989 German study found that people who steamed twice a week got half as many colds as those who didn't. One theory: When you take a sauna you inhale air hotter than 80 degrees, a temperature too hot for cold and flu viruses to survive.

^ Back to top

#6 Get Fresh Air

A regular dose of fresh air is important, especially in cold weather when central heating dries you out and makes your body more vulnerable to cold and flu viruses. Also, during cold weather more people stay indoors, which means more germs are circulating in crowded, dry rooms.

^ Back to top

#7 Do Aerobic Exercise Regularly

Aerobic exercise speeds up the heart to pump larger quantities of blood; makes you breathe faster to help transfer oxygen from your lungs to your blood; and makes you sweat once your body heats up. These exercises help increase the body's natural virus-killing cells.

^ Back to top

#8 Eat Foods Containing Phytochemicals

"Phyto" means plants, and the natural chemicals in plants give the vitamins in food a supercharged boost. So put away the vitamin pill, and eat dark green, red, and yellow vegetables and fruits.

^ Back to top

#9 Eat Yogurt

Some studies have shown that eating a daily cup of low-fat yogurt can reduce your susceptibility to colds by 25 percent. Researchers think the beneficial bacteria in yogurt may stimulate production of immune system substances that fight disease.

^ Back to top

#10 Don't Smoke

Statistics show that heavy smokers get more severe colds and more frequent ones.

Even being around smoke profoundly zaps the immune system. Smoke dries out your nasal passages and paralyzes cilia. These are the delicate hairs that line the mucous membranes in your nose and lungs, and with their wavy movements, sweep cold and flu viruses out of the nasal passages. Experts contend that one cigarette can paralyze cilia for as long as 30 to 40 minutes.

^ Back to top

#11 Cut Alcohol Consumption

Heavy alcohol use destroys the liver, the body's primary filtering system, which means that germs of all kinds won't leave your body as fast. The result is, heavier drinkers are more prone to initial infections as well as secondary complications. Alcohol also dehydrates the body -- it actually takes more fluids from your system than it puts in.

^ Back to top

#12 Relax

If you can teach yourself to relax, you can activate your immune system on demand. There's evidence that when you put your relaxation skills into action, your interleukins -- leaders in the immune system response against cold and flu viruses -- increase in the bloodstream. Train yourself to picture an image you find pleasant or calming. Do this 30 minutes a day for several months. Keep in mind, relaxation is a learnable skill, but it is not doing nothing. People who try to relax, but are in fact bored, show no changes in blood chemicals.

^ Back to top

The People's Medical Society is a nonprofit consumer health advocacy organization. Charles B. Inlander is president, and co-author of 77 Ways to Beat Cold and Flu.

Reviewed by Charlotte E. Grayson, MD, September 2003.
Originally published October 2001.

SOURCE: Charles B. Inlander, president of The People's Medical Society, a nonprofit consumer health advocacy organization, and author of 77 Ways to Beat Cold and Flu.

© 2003 WebMD Inc. All rights reserved.
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Unread postby OilsNotWell » Tue 10 May 2005, 00:26:51

This caught my attention:

$this->bbcode_second_pass_quote('', 'C')ommentary

Proof of Human to Human Transmission of Bird Flu in Vietnam

Recombinomics Commentary
April 17, 2005

>> Peter Horby, the WHO medical epidemiologist in Hanoi, said that while the mortality rate from H5N1 infections was falling, the virus appeared to be adapting to human hosts, which was taken to be an indication that transmission between humans would become easier.

"The fact that it's been around for a year and we haven't seen a pandemic is no reason to be complacent," he said.

"I'm more concerned than I was a year ago." He estimated the probability of a pandemic at "more than 50 per cent".


Dr Klaus Stohr, the WHO global influenza programme chief, reported an increase in the number of cluster cases reported recently, with the biggest a family of five cases.

There have been seven cluster cases in Vietnam, all within single families, most recently in the northern province of Haiphong.

No relative has been proved to have passed the disease to another, but Dr Horby said: "The onset dates could be consistent with human to human transmission." <<

The above comments by Peter Horby and Klaus Stohr dance around the human-to-human transmission issue. They cite evidence for more efficient human-to-human transmission, but then try to limit the implications by saying that the proven transmissions are not proven.

The most straightforward proof of human-to-human transmission is bimodal distribution of onset dates. When two people who have contact with each other develop symptoms at different times, the simplest explanation is that the patient who developed symptoms at an earlier date transmitted bird flu to the contact that developed symptoms at a later date.

All of the relevant facts are acknowledged. The number of clusters has increased, as have their size. The relevance of the bimodal distribution is acknowledged by the statement that "onset dates could be consistent with human-to-human transmission".

Use of "could" was appropriate last year, when the number of clusters was smaller. However, now the number of familial clusters has grown to more than double the seven acknowledged above and virtually all have bimodal distributions, which as an aggregate provide overwhelming evidence for human-to-human transmission. It is misleading to continue to use "could". The onset dates in virtually all of the familial clusters PROVE human-to-human transmission.

Moreover, the statement that the cluster cases are all within single families is simply false. The cluster in Thai Binh involving the two nurses extended beyond a single family. The brother, sister and their nurse were all confirmed to be H5N1 positive, and the negative tests on the second nurse remain suspect.

The number of confirmed human cases remains very low, and symptoms in a second nurse in the same hospital as the three confirmed cases raises the suspicion level regarding infection to a high level. Although the nurse tested negative twice, there are no reports on an etiological agent that caused the bird flu symptoms in the second nurse.

When top WHO representatibves define evidence for human-to-human transmission, but fail to acknowledge the existence of human-to-human transmissions proven by the clear evidence, the number of reasons why the monitoring and control of avian influenza in Asia is scandalous, increase.
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Unread postby OilsNotWell » Tue 10 May 2005, 00:34:41

$this->bbcode_second_pass_quote('', '(')4/14/05) DR KLAUS STOHR: For the H5N1 virus, vaccine development in quite a number of companies is quite well advanced. Clinical trials or the testing in humans has already started - in April, for a vaccine from one company - but there are 11 more companies which have not gone beyond the animal trials, and without testing this vaccine in humans, it cannot be produced at such a large scale. The current situation, if a pandemic were to occur today, that around about 600,000 to 2 million vaccine doses might be available in June or July in North America. In Europe, it would take about a year before enough vaccine would be available, just because the clinical trials have not started and the vaccine production capacity would not suffice to do that faster, and globally it would certainly take, currently, several years to provide enough vaccine for the majority of the world population. And that's certainly not considered to be a very far advanced pandemic preparedness as far as vaccines are concerned.


article here:

CurEvents - Dr. Klaus

Dr. Klaus is WHO's global influenza coordinator...


After reading this, I am reminded of the line from "Titanic", where the boat designer says to Rose: "Now, you remember what I said regarding those lifeboats, don't you?"......

EDIT: Oops, I meant Rose...
Last edited by OilsNotWell on Tue 10 May 2005, 01:05:53, edited 1 time in total.
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Unread postby OilsNotWell » Tue 10 May 2005, 01:04:33

You should know that the World Health Organisation has recently warned that the world was now , and I quote, "in the gravest possible danger of a pandemic".....


"No country in the world has enough anti-virals to protect essential personnel for the likely six-month duration of a flu pandemic, let alone to protect the general public," Mr Abbott says (the Australian Health Minister)..

(whistling past the graveyard).....
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Unread postby OilsNotWell » Tue 10 May 2005, 14:17:12

If you REALLY want to stay up on bird flu news, bookmark this site:

NewsNow - Bird Flu Page

Constantly updated.
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Unread postby OilsNotWell » Tue 10 May 2005, 16:56:53

Guess what? Evidence of Bird flu found in INDIA..they weren't even looking for it...found it just by chance. But yet some still snooze....

$this->bbcode_second_pass_quote('', 'B')ird flu strain found in three Chennai poultry workers
Wednesday May 11 2005 00:00 IST
NEW DELHI: Scientists from a partner laboratory of the Indian Council of Medical Research (ICMR) have found the first signs of an Avian influenza virus in three workers from a poultry farm near Chennai.

Only specific protein signatures of the “highly pathogenic” H5N1 strain were spotted at ICMR's influenza referral laboratory in Chennai's King Institute of Preventive Medicine-the disease itself has not been detected.

Researchers found the H5N1 signs in samples collected in 2002, which was confirmed by the world's foremost infectious diseases laboratory, The Centers for Disease Control and Prevention (CDC), Atlanta late last year.

But so far, India's health research bureaucracy seems to have underplayed the threat, not even taking steps to research it further.

Dr Nirmal K Ganguly, director general of ICMR told this website’s newspaper that he was “not aware of such a finding”, suggesting that if such a high profile exotic virus were to surface in India, his staff would alert him.

However, he was “at the moment in total darkness” about the discovery. Dr Jackie Katz of the CDC's Influenza Branch confirmed to this website’s newsapaper that the “three people tested positive for antibody to a highly pathogenic H5N1 virus”. Dr Katz added that “there is no cause for alarm.”

Till date, only these protein signatures have been found, and irrefutable evidence that the deadly H5N1 strain is present in humans in India or not, can emerge only when the virus is isolated and sequenced.

But virus isolation and sequencing has not been attempted in India, as there is a lack of such a secure bio-safety facility, said Dr A C Mishra, director of the National Institute of Virology, Pune.

He added that a high-level meeting is being organised at ICMR soon to take stock of the situation and decide on the steps to be taken.

The H5N1 strain normally infects only birds-in poultry it causes epidemics-but it is worrisome because it has been found to jump the species barrier and infect humans, like what happened in Hong Kong in 1997 when six people died and the entire 1.5 million bird poultry stock of the island had to culled.

The Avian Influenza Virus has been in the headlines since its outbreak in East Asia earlier last year and the World Health Organisation (WHO) has issued a global alert about this highly contagious bug.

The WHO Regional Representative to India, Dr Salim Habayeb expressed complete surprise that he was not informed about this finding by the government even though he gets a weekly report of prevalent communicable animal and human diseases.

Expressing concern, Dr. Habayeb said the H5N1 strain is “a very evil virus” as it mutates very fast-a benign non-pathogenic strain could quickly become a deadly virus since this particular family of bugs are known to swap genes at a very rapid pace.

But Habayeb says there is no reason to panic
as India has adequate mechanisms for control of disease outbreaks, citing the effective handling of the SARS incident.

Indian researcher Dr Nalini Ramamurthy, director of The King Institute of Preventive Medicine, Chennai said their group chanced upon these three cases of “sero-positivity” in a poultry farm in Kattangalathur, about 45 km south of Chennai, while routinely monitoring the human population for influenza antibodies.

All the three who show positivity have never travelled overseas nor is any poultry imported into India from regions where epidemics have occurred-East Asia-so a native exposure to the virus is the only alternative, she says.

Dr Ramamurthy believes that the nearby Vedanthangal Bird Sanctuary, which is visited by many migratory water birds, could be the source of the infection.

But a study urgently needs to be undertaken to see if the sero-prevalence has spread to other farms or not, says Dr Ramamurthy.

According to the WHO's standard operating procedures, whenever signatures of such highly pathogenic strain are found, intensive studies of both the bird and humans in the area should be undertaken so the source can be identified.

Even Katz suggests that continued testing of humans and poultry needs to undertaken “so that we may better understand the risks of human infection with avian influenza viruses”.

NewIndPress


Nope. No reason to panic. None whatsoever. In fact, not even a BILLION reasons to panic, nope.
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Unread postby bobcousins » Tue 10 May 2005, 19:50:33

Damn, I've been so caught up in one doom scenario I nearly missed a different one!

How is a global pandemic going to affect Peak Oil though - good or bad?

*choo*. Excude be.
It's all downhill from here
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Unread postby blackaddr » Tue 10 May 2005, 22:49:06

OilsNotWell: I take back my former reaction. I've known about this problem for a while, but after listening to that mp3 file and hearing that there are 3 different viruses floating around in some korean pig.....it does sound kinda serious.

all this genetic manipulation stuff sounds very scary to me. Did you guys hear about the new US-EU trade war? all US grain imports have been stopped over fear of it being GM.

http://news.bbc.co.uk/1/hi/business/4450735.stm

seems like US corn has been manufactured to have antibiotic properties. The EU recons that if this property is then passed on to humans antibiotics could become useless.......
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Unread postby OilsNotWell » Wed 11 May 2005, 02:07:52

$this->bbcode_second_pass_quote('', 'H')ow is a global pandemic going to affect Peak Oil though - good or bad?

*choo*. Excude be.


Oh, your funny.

Funny? Funny how? Funny like a clown? Do I make you laugh?

-Joe Pesci (Goodfellas)

Well, if we see, say, 100 million deaths, or maybe 200-300 million, might push peak out a bit. Depends on where most of the deaths occur, if they were high-energy consumers, etc. Kind of gristly to think about, though. If a 12 Monkeys nightmare scenario play out, about a "Black Death" occurs like in Europe (1/3 died), then, well obviously peak oil will not be a problem for many years. What even a somewhat mild pandemic I th ink would do probably do is shut down, paralyze, or even collapse whole economies....but frankly at that point I wouldn't give a rat's ass about that if I or those around me were still alive...
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Unread postby OilsNotWell » Wed 11 May 2005, 02:12:27

Someone's viewpoint....those still reading this thread will care and see the obviousness of it...

$this->bbcode_second_pass_quote('', 'H')ong Kong Update
The West will be left in the dust.

--------------------------------------------------------------------------------

1. Every day or nearly every day, now, one or another HK newspaper has a FEATURE article or a LEAD article in a newspaper section on the topic of bird flu.

2. The street crossing buttons used to cause the street lights are now being changed out. Substituted instead are switches that operate simply by placing one's hand NEAR the switch pad. Why? Bird flu prevention measure.

3. At every high and mid level restaurant there is an electric eye operated alcohol hand spritzer/sprayer so customers entering the restaurant or leaving can disinfect their hands. And when they are seated, all are handed alcohol wipes. Why? Bird flu prevention measure.

4. Here's a ditty from South China Morning Post, dated April 13, 05, Page C1, the City section, with a headline, "Prepare for pandemic, urges flu kit" with the sub heading, "To be distributed to households soon, it recommends that residents buy in an adequate stock of masks and pills." by Mary ann Benitez, the story first paragraph states, "A flu information kit to be issued to households urges them to stock up on surgical masks and anti-fever medicine in preparation for a possible flu pandemic, the city's top disease control expert said yesterday."

When the possible flu pandemic arrives in the US, it will "possible" devastate "possibly" a very large number of "possible" people. Webster's and Stohr's plan of a Tamiflu blanket at locales of outbursts is considered unworkable by HK residents. Webster and Stohr suggest an alternative, I think, which is to run and hide in a corner and wish very hard it will go away.

The failure of WHO, CDC, the western governments and health departments to do anything more than to think about sanitation, transportation, and power, and for health care officials to look at "Oh my!" outcomes as they watch their staffs become overwhelmed and rapidly infected in every simulation of a bird flu outbreak are many steps beyond Dr. Niman's kind description of "scandalous" and "beyond scandalous".

Rome burns. Hong Kong prepares. The UK issues a Pandemic Plan. Toronto in a few weeks will issue a Pandemic Plan. And the good ole' US of A, operated by democracy loving cyclops' is about to be left in the dust.

My opinion: Ignore what the government and WHO and CDC are saying. Follow what HK is doing. Track HK announcements. Track and mimic HK pandemic preparations; and do them "now". To do otherwise is to not be HK rational.

I'll repeat another paragraph from the news article reference above, 'Normally during peace time people do not bother about these. The kit at home would serve to tell people what to do. They can have time to read and prepare. So we need to tell them in advance to stock up on things, said Dr. Leung (Center for Health Protection controller). "We are going to ask our general families to stock up on masks at home, like keeping them in a first-aid kit, prepare anti-fever medicines like Panadol, and watch out for government news. Then, during a pandemic you read it again for all the detailed information, including the hotline number."

How many masks? "Dr. Leung recommended city residents ensure they have a sufficient supply of masks to last three weeks."

HK specificially advises not to stock up on Tamiflu yet, but to confirm that adequate supply is available at their doctor's office (in HK, doctors sell drugs to patients, directly, in addition to pharmacies also selling drugs to patients.)

The US Dept of HHS is a complete failure. Fear of being ridiculed over the SARS epidemic "failure" (instead of standing up and saying, Get Lost, We Did the Prudent Thing), the DHHS roars like a pussy cat, and lots of US lives "possibly" will "possibly" perish, thank you to the current current US administration. [Do note their names should you survive til the next election.]
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Unread postby smallpoxgirl » Wed 11 May 2005, 02:26:03

Interesting. So could a flu epedemic create enough demand destruction to forestall peak oil for another 5-10 years?
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Unread postby OilsNotWell » Wed 11 May 2005, 02:40:59

$this->bbcode_second_pass_quote('', 'I')nteresting. So could a flu epedemic create enough demand destruction to forestall peak oil for another 5-10 years?


Perhaps - that seems like a reasonable estimate, but I guess it depends on how severe it may be, and that, no one really knows.

What's really on our side, though, is advanced medical knowledge, and lightspeed communication, so impacts, though they could be severe, will be mitigated. For instance, once word is out truly out that a pandemic is underway, say from Hong Kong, or Vietnam, or China, or India, depending on where you live, you'll have some time to modestly prepare, I hope. I imagine if it gets super bad, the US would literally seal the borders (or at least try), preventing incoming/outgoing flights, general quarantine orders, etc., which as draconian as they sound to a liberty-lover such as myself may in fact be absolutely necessary. Plus, this would be an ongoing, trasnforming process, and when recognized for the danger that it is, I have hope that citizens and governments will massively mobilize to fight the threat. With SARS, China built an entire hospital from the ground up in 9 DAYS.
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Unread postby blackaddr » Wed 11 May 2005, 14:16:10

OilsNotWell, isnt it true that these pandemics will most likely start in areas where people are close to farm animals like in india/china/hongkong?

wasnt it jared diamond who said that all these problems really started when humans domesticated animals for food. And that living in close proximity to them alowed these viruses to jump from animal to human and back again mutating all the time?
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Unread postby OilsNotWell » Wed 11 May 2005, 16:45:09

$this->bbcode_second_pass_quote('', 'O')ilsNotWell, isnt it true that these pandemics will most likely start in areas where people are close to farm animals like in india/china/hongkong?

wasnt it jared diamond who said that all these problems really started when humans domesticated animals for food. And that living in close proximity to them alowed these viruses to jump from animal to human and back again mutating all the time?


(1) I don't really know. From what I've read, and I agree, that if one looks closely enough, we can already see the pandemic evolving:

$this->bbcode_second_pass_quote('', 'P')andemic in slow motion?

It seems to be dawning on Vietnamese and WHO officials that the bird flu pandemic might already be on us. In today's Washington Post we read about the good news/bad news picture of a disease, influenza A/H5N1, becoming less lethal while at the same time perhaps becoming more widespread and easily transmissible. We raised this scenario here, here and here, and Henry Niman at Recombinomics has been hinting at the same thing, pointing out the larger clusters and reduced mortality of the northern Vietnamese cases compared to the southern ones. Now WaPo is catching up:

"The virus could be adapting to humans," said Peter Horby, an epidemiologist with the World Health Organization in Hanoi, the Vietnamese capital. "There's a number of indications it could be moving toward a more dangerous virus."

The mortality rate for bird flu in Vietnam this year is about 35 percent, almost exactly half that of last year, according to Health Ministry statistics. The mortality rate of the 1918 Spanish flu pandemic, by comparison, was less than 5 percent, but the outbreak killed an estimated 40 million people worldwide.

Officials said the drop in the bird flu mortality rate was more marked in northern Vietnam than in the south. While the virus in southern Vietnam is still killing at the same pace as last year, the rate in the area around Hanoi and elsewhere in the north has dropped from that level to as low as 20 percent. Vietnamese health experts said their suspicion that the disease is shifting is further supported by preliminary research showing a genetic change in the virus in the north resulting in the production of a protein with one less amino acid than in the south.
To our knowledge this is the first mention of a genetic difference between northern Vietnam H5N1 and southern Vietnam H5N1. Reading between the lines, it suggests the polybasic cleavage site seen in highly pathogenic avian influenza is shorter in the northern variant. To be infective, the HA (hemagglutinin protein spike) on the virus must be cleaved by the host into two pieces, HA1 and HA2. The enzymes that can fit into the narrow cleavage site of low virulence viruses are found in the respiratory tract in humans or intestinal tract of fowls, but if the cleavage site is "opened up" by some extra amino acids, more tissues can accomplish this and hence become vulnerable to infection, leading to pantropism, that is, infection of many organ systems besides the lung. Thus the nervous system, kidneys and other organs also start to fail rapidly in human infections with H5N1. If this is the nature of the genetic differences, it might mean that the northern variant is less prone to involve other organ systems.

But lower virulence H5N1 is not avirulent H5N1. In addition, much is not known of the specific virulence factors. Moreover, some flu experts think that the virus adapts further once it takes hold in the human population, with the second wave of a pandemic more severe than the first, as happened in 1918 - 1919. Even if the mortality is as low as 5% (probably the upper limit for mortality in 1918 flu), since there is essentially little natural immunity to H5N1 (except an unknown amount against the N1 component), a pandemic could infect 20% to 30% of the world's population, or 1.5 billion people. If only half of those became clinically ill and 5% of those died, it would amount to 40 million deaths, worldwide, roughly 130 Indian Ocean tsunamis.

The early signs of most pandemics are visible if you are watching closely. If you aren't, they seem to burst on the scene with scores, hundreds and then thousands of cases. Maybe CDC and WHO are watching closely. But they have waited so long to turn the wheel, now it is a bit like an auto accident that seems to be happening in slow motion without any ability to do anything but brace ourselves to spin out of control.

Found here:

http://effectmeasure.blogspot.com/2005/04/pandemic-in-slow-motion.html


By the way, that is an excellent blog site for news and commentary on bird flu and other major worldwide epidemiological issues.

As for (2), I haven't read 'Collapse' yet, but have read more than a few detailed reviews, and I agree with his hypotheses on their face. But I don't know enough about the human/animal viral interaction dynamics yet to have an educated opinion on it yet. So don't know on this either!

Here's a doomer scenario:

$this->bbcode_second_pass_quote('', '[')I]f the mortality for any wave of the influenza is 35%, what it now is in North Vietnam, since there is essentially little natural immunity to H5N1 (except an unknown amount against the N1 component), a pandemic could infect 35% to 45% of the world's population, or 2.4 billion people. If all of those became clinically ill and 35% of those died, it would amount to 840 million deaths, worldwide, roughly 2,750 Indian Ocean tsunamis.

My humble conclusion is tripartite. First Dr. Niman's long-standing estimate of 1 billion dead is within the range of reality. Second, there will be no infrastructure left for assessments of blame and recriminations (never mind little in the way of operable infrastructure to return to life as we now know it); as Samuel Pepys observed after the Black Plague, housing will "open up" and prices will drop quite dramatically due to all the new vacancies.

My guess, 800 million; but who really cares about the numbers?

What you observe, governments fully unprepared to be of value to their constituents when the pandemic waves roll through.


and this one:

$this->bbcode_second_pass_quote('', 'R')evere:>Even if the mortality is as low as 5% [snip], since there is essentially little natural immunity to H5N1 [snip], a pandemic could infect 20% to 30% of the world's population, or 1.5 billion people. If only half of those became clinically ill and 5% of those died, it would amount to 40 million deaths, worldwide [snip].

If deaths due to secondary complications due to lack of competent healthcare professionals is included in your numbers, then "great". If not, the death rate should probably double due to the lack of access to hospitals and a dearth of paramedics during the pandemic.


both comments on the above linked page.

And here's another "coming influenza pandemic" blogspot:


http://influenzapandemic.blogspot.com/

This looks to be updated quite frequently.
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Unread postby OilsNotWell » Wed 11 May 2005, 16:47:11

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Unread postby OilsNotWell » Wed 11 May 2005, 16:50:08

Repeating an important announcement from the World Health Organization:

[QUOTE]>> In Asia, there are hints that the virus is indeed changing. "Incomplete evidence suggests that there may be a shift in the epidemiology of the disease," says Stöhr. "More clusters are being seen than last year, older people are now coming down with the diseases, and more cases are milder." Taken together, these characteristics could indicate that the virus is becoming less virulent and more infectious, he says, which could signal the start of a pandemic. <<
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Unread postby OilsNotWell » Wed 11 May 2005, 16:55:26

$this->bbcode_second_pass_quote('', 'B')roadened Host Range and Efficient Human Transmission of Evolved H5N1

Recombinomics Commentary
April 30, 2005

>> there is a steadily increasing number of clusters of disease, where it appears to have spread between people. There are now at least seven of these, almost all in the northern province of Haiphong. WHO officials say this is unprecedented.

Finally, the virus itself seems to have changed physically. Vietnamese health experts say that it has evolved in the north of the country by dropping an amino acid.

The US government's Centers for Disease Control and Prevention, which has analysed many of specimens of the virus from Vietnam, adds that new strains of it "are becoming more capable of causing disease for mammals". <<

The comments above suggest that the northern H5N1 not only has been associated with a lower case fatality rate in larger clusters, but the dropped amino acid is also associated with a broader host range.

The confirmation of H5N1 in the family of five in Haiphong signaled the start of the flu pandemic. All five family members were admitted on the same day and all recovered relatively quickly. The recovery in a week or two is similar to a bad case of human flu, suggesting there may be many more unreported cases. The above comments suggest there have been seven clusters in Haiphong alone. The neighbors of the family of five had been admitted to the hospital a few days after the family of five. Although test results were not reported, the above comments suggest these neighbors may represent another cluster in Haiphong.

On April 15 northern Vietnam had sent the CDC a large number of the 1000 samples they had collected from people and animals. The above comments may indicate earlier results, since the clusters in northern Vietnam have been reported since the beginning of the year. Earlier there were also comments about the genetic composition of H5N1 changing, and recently the lost amino acid was acknowledged. The lost amino acid sounds like isolates from China in 2003, which have also lost an amino acid in the polybasic region of HA. It sounds like the new isolates from northern Vietnam are recombinants. The recombined genes are more efficient at infecting mammals, including humans, but this recombination resulted in a reduced case fatality rate.

These changes have striking parallels with the 1918 pandemic which began as a mild infection in the sping of 1918 and evolved into an efficient killer in the fall. The current information coming out of northern Vietnam suggests a similar sequence of events may be happening in 2005, and the flu pandemic has begun as indicated. Moreover, the finding of WSN/33 in swine in Korea suggests the pandemic in 2005 may be beginning on two fronts, with avian viruses becoming more human-like in Vietnam and human viruses becoming more avian-like in Korea. Unfortunately, both sets of viruses can infect birds which could create more mixing and matching of genetic information. This genetic instability could frustrate vaccine efforts based on the last 2004 isolates form Vietnam.

These problems may make the pandemic of 2005 strikingly similar to the pandemic of 1918.


Broadened Host Range and Efficient Human Transmission of Evolved H5N1

One of the reasons why I entitled this thread thusly.
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Unread postby OilsNotWell » Wed 11 May 2005, 17:08:44

$this->bbcode_second_pass_quote('', 'T')uesday, May 10, 2005

Flu pandemic will swamp hospitals: report

Toronto cannot adequately prepare for the fallout from an inevitable large-scale outbreak of influenza, city health officials are warning.

In a report presented Tuesday to the city's board of health, Toronto's medical officer of health predicts that up to 914,000 people will come down with the flu during the next pandemic, and up to 12,000 of those will need to be hospitalized.

As many as 5,000 Toronto residents could die from the flu during the pandemic, the report says.

- READ THE REPORT: Pandemic Influenza Planning in the City of Toronto

Flu pandemics sweep the globe every 35 to 40 years. Since the last such outbreak was in 1968, health officials are now working on a plan for how to deal with the inevitable illnesses and deaths that will result.

Influenza is transmitted quickly, and the sudden surge in demand for beds and health-care workers is expected to swamp hospitals and strain resources.

The city will also come under incredible strain as it tries to function with as many as a third of its workers off sick, warns the head of communicable disease control at Toronto Public Health.

"Even if you think about where you work or your children go to school, people will be off ill," said Dr. Barbara Yaffe.

"There will be issues around continuing the functioning of society and the delivery of essential services."

Toronto Public Health is now in the final stages of preparing its pandemic response plan.

The plan will deal with who gets flu vaccines and how health-care facilities are expanded to cope with surging numbers of patients.

The first draft of the plan is scheduled to be finished in June, and will be posted on the Toronto Public Health website.

© the CBC, 2005


Toronto News


Well, at least they're planning...

PS. I added the bold.
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Unread postby OilsNotWell » Fri 13 May 2005, 02:05:58

$this->bbcode_second_pass_quote('', 'G')overnment on alert over possible human avian flu

After the latest bird flu outbreak in South Sulawesi, the Ministry of Health is intensifying surveillance in case of human infection by the pathogenic virus in the province, officials have said.

Last week, the ministry was reported to have sent six specimens from poultry workers in South Sulawesi, with suspected bird flu infection, for laboratory tests in Hong Kong.

Earlier, at least 77 more samples had been sent in March and April for similar tests in Hong Kong.

Despite the bird flu outbreak, there were no confirmed cases of human infection in Indonesia. According to WHO representative Georg Petersen, the H5N1 virus can infect humans.

"We are sending blood serum from workers with a high possibility of having contact with infected animals as a zero surveillance procedure," the health ministry's director general for communicable diseases, Umar Fahmi Achmadi, told The Jakarta Post.

He denied that the samples were sent for a laboratory test because they suspected the workers had contracted human avian flu.

However, the ministry's handbook on avian flu states that specimens are taken for testing only from probable bird flu cases, which it defines as suspected cases.

Jakarta (India Post)


tick-tick-tick-tick-tick-tick-tick........

$this->bbcode_second_pass_quote('', 'B')ird Flu Data Not Sufficient, WHO Officials Warn
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Too little data and too few avian flu samples are flowing out of Southeast Asia, making it difficult to assess whether the threat of a human bird flu pandemic is growing, a top official from the World Health Organization (WHO) said Wednesday.

Dr. Klaus Stohr, chief of the WHO's influenza program, has echoed the fear of many experts that the bird flu virus could soon combine with a human strain of the disease, causing an outbreak among people that no existing flu vaccine could control.

WHO: Too Little Data

What you don't know can hurt you...
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