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Lab creates super mouse - twice as energy efficient

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Lab creates super mouse - twice as energy efficient

Unread postby lorenzo » Fri 02 Nov 2007, 12:54:00

Once, I started a thread about the future of human bodies and brains. I said: we will be making more efficient creatures that need far less energy to perform much better - beings with hyper-efficient metabolisms. Such highly energy efficient bodies could then spend more energy on brain functions and on growing far bigger brains.

These fat brains would in turn of course discover and develop much better energy technologies as well as much better humans - ever lighter, more efficient, smarter, happier people - a positive feedback loop. We would also require far less food.

In short, my prediction of a liveable planet capable of supporting hundreds of billions of small, hyper-efficient, hyper-intelligent, ultra-happy, long-living humanoid beings (basically heads on legs) is not that far off.

Let's start by genetically modifying a mouse, so that it becomes twice as efficient. Twice as efficient - that is only the beginning:

$this->bbcode_second_pass_quote('', '[')b]Lab creates 'long-distance mouse'
A genetically modified "supermouse" which can run twice as far as a normal rodent has been created by scientists working in the US.

It also lives longer, and breeds later in life compared with its standard laboratory cousin.

The research has been conducted at Case Western Reserve University in Cleveland, Ohio.

Details of the scientists' new transgenic animals are published in the Journal of Biological Chemistry.

The mice were produced to study the biochemistry at play in metabolism and could aid the understanding of human health and disease.

The GM rodents can run five to six kilometres at a speed of 20 meters per minute on a treadmill, for up to six hours before stopping.

"They are metabolically similar to Lance Armstrong biking up the Pyrenees; they utilise mainly fatty acids for energy and produce very little lactic acid," said Professor Richard Hanson, the senior author on the journal article.

He told BBC News: "The muscles of these mice have many more mitochondria. These are the little 'engines' in the cell that produce energy. For some reason, the number of mitochondria are around 10 times more than we see in the muscle of their littermates."

The mice over-express a gene responsible for the enzyme phosphoenolypyruvate carboxykinases (PEPCK-C). Normal expression is in the liver, in the production of glucose.

The scientists found their new mice would eat twice as much as normal mice - but weigh half as much. They could also give birth at three years old - which in human terms is akin to an 80-year-old woman giving birth.

Other research groups have produced similar novel rodents by altering different aspects of their genetics. One criticism of the work is that it could open the door to abuse, with the spectre of athletes resorting to gene therapy to try to improve their performance.

But Professor Hanson played this down. "Right now, this is impossible to do - putting a gene into muscle. It's unethical. And I don't think you'd want to do this. These animals are rather aggressive, we've noticed."

Scientists say such work is more likely to help them understand human conditions, such as those which lead to wasting of the muscles.

http://news.bbc.co.uk/2/hi/science/nature/7074831.stm


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Re: Lab creates super mouse - twice as energy efficient

Unread postby lorenzo » Fri 02 Nov 2007, 13:05:04

$this->bbcode_second_pass_quote('Shannymara', 'W')ow, the days of a small genetically engineered super-class of elites and a giant underclass of retarded human slaves grow ever closer. How wonderful! Or were you thinking the generous wealthy governments of the world will engineer all the poor people's kids as a charitable service, kind of like how they're working so hard to end poverty right now?

Give me a break.


Fair point. But I was talking about marxist mice.

Science is value-free. We decide what we do with it, we are in power. If it is up to me, we create hyper-efficient, uber-happy, hyper-light, ultra-smart, explicitly hyper-left wing humanoid creatures.

It can be done, it's only a matter of time before we identify the Marx gene. In fact, genes for altruism have already been found. We only need to tweak them.

This is a matter of policy.
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Re: Lab creates super mouse - twice as energy efficient

Unread postby Falconoffury » Fri 02 Nov 2007, 14:22:12

You mean like this?

Image

I wonder if aliens look like that because of genetic engineering for the exact purposes you are describing.
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Re: Lab creates super mouse - twice as energy efficient

Unread postby joewp » Fri 02 Nov 2007, 14:26:53

$this->bbcode_second_pass_quote('lorenzo', '
')In short, my prediction of a liveable planet capable of supporting hundreds of billions of small, hyper-efficient, hyper-intelligent, ultra-happy, long-living humanoid beings (basically heads on legs) is not that far off.


I must admit, you make me laugh Lorenzo!

By the way, evolution has already gotten rid of the legs:

Image
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Re: Lab creates super mouse - twice as energy efficient

Unread postby Pixie » Fri 02 Nov 2007, 14:58:17

$this->bbcode_second_pass_quote('lorenzo', 'O')nce, I started a thread about the future of human bodies and brains. I said: we will be making more efficient creatures that need far less energy to perform much better



From my reading of the article, these mice go in the opposite direction. They eat twice as much. These are like green revolution mice. Fertilize the bejesus out of a green revolution crop, pour water on it, and it will produce a huge head of grain. With these mice, feed them like nuts, and they will beat the tar out of their neighbors, bike up the Pyranees, and bear lots of children until into their old age.

These are not heads on legs. These are super soldiers. Cannon fodder from hell.
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Re: Lab creates super mouse - twice as energy efficient

Unread postby Concerned » Fri 02 Nov 2007, 15:43:23

hahahahaha more priceless stuff on PO.com

We are genetically very efficient, it's not our bodies fault we choose to ingest a high sugar and fat diet, sit down all day and not exercise.

I think that we should have space elevators and colonize the planets.

We should work on downloading all human brains onto massive integrated data centers. Then we would not need food, this would all be powered by the billions of kw solar energy hitting the earth every day and we could all live happily ever after.

I think aliens are green because they have genetically modified their skin to have a chlorophyll gene so that they can convert the suns energy into energy for their bodies. This is another project humanity should work on as a priority. Besides it would be really cool to have green skin just like Shrek !
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Re: Lab creates super mouse - twice as energy efficient

Unread postby aflurry » Fri 02 Nov 2007, 15:58:09

$this->bbcode_second_pass_quote('lorenzo', 'T')hese fat brains would in turn of course discover and develop much better energy technologies...


Like burning brain-fat!

Worked with whale blubber.

edit: "ultra-happy"

ha ha ha ha ha ha ha ha ha ha ha ha.
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Re: Lab creates super mouse - twice as energy efficient

Unread postby BlisteredWhippet » Fri 02 Nov 2007, 15:59:04

$this->bbcode_second_pass_quote('lorenzo', 'O')nce, I started a thread about the future of human bodies and brains. I said: we will be making more efficient creatures that need far less energy to perform much better - beings with hyper-efficient metabolisms. Such highly energy efficient bodies could then spend more energy on brain functions and on growing far bigger brains.


While I agree that genetic manipulation will inevitably lead to the modification of human genomes in vitro for the promulgation of certain traits, I hardly think that these changes will resemble the ones you describe.

Besides which, if anyone thinks to try it, they can alter their metabolism to the processing of fatty acids, train their bodies to develop stamina and endurance, and develop their intelligence through acts of will alone. This is my reality. I think this is something I chose to do through my own volition. In other words, my belief is that all it takes is brains to achieve the potentials in average, ordinary bodies. All it takes to develop those brains is smart inputs- the dietary, emotional, and cognitive inputs that a parent should provide (Thanks Mom & Dad), the cumulative inputs of experience and education, and the practice of putting wisdom into action.

The problem as I see it with modern genomics is that is adds to a persistent public delusion that we are shake 'n' bake creatures largely doomed to predestination. As Tony Robbins would say, it is a self-limiting belief system which prevents people from overcoming their limitations. (Insert anecdote about guy with no legs who runs Marathon here)

I think that genomics can and should alter the genome to prevent disease and enhance function. This is conventionally justified by the moral precedent of basic medical ethics. But I think the ultimate manifestation in this direction will be toward the enhancement of functionality of the individual, rather than the socially-engineered construct Lorenzo suggests here, because humans are evolved creatures that exist outside of a laboratory. Its unclear and unproven whether what appears to work in rats will work in humans, or will work in the real world.

Evolution has produced as highly efficient creature that survives and thrives across disparate environments. It is adaptable, with a diversity of traits. Insofar as that is the case, small-framed humans with fat brains that appear to run on Mountain Dew and have some tendencies toward altruism are already here, creating and maintaining complex technological systems that make them happy in a positive feedback loop.

The questioin is: are more "efficient people" therefore subject to Jevon's paradox?
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Re: Lab creates super mouse - twice as energy efficient

Unread postby Sys1 » Fri 02 Nov 2007, 16:39:06

"The muscles of these mice have many more mitochondria. These are the little 'engines' in the cell that produce energy."

Damn, the first second i saw that, i thought about Qui-Gon Jinn telling Obiwan Kenobi that Anakin as so much midichlorians in his body that he's obviously able to have the FORCE, therefore he will have a great fate as a JEDI!

(Lorenzo, this article is pure BS)
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Re: Lab creates super mouse - twice as energy efficient

Unread postby aflurry » Fri 02 Nov 2007, 16:50:50

What confounds me is the utter refusal to entertain the idea that there is no "new energy technology" to be found. The willingness to resort to this utterly superstitious idea that there IS an answer but we are just too stupid to find it. There has to be. There couldn't not be. "Of course" we will find it. We are too important to just disappear into the night.

Well we can and probably will just disappear into the night as great civilizations full of smart people before us have and for the same reasons.

And honestly, when you look at actual real technologies, there is some impressive tinkering - fair enough, but at base it all fails to live up to the hype. This is true particularly with the technologies of primary energy production, which i would characterize as the "technology of finding what else we got to burn." (paraphrasing from another member here, sadly.)

early on you had some nice innovation with windmills and waterwheels, but everything else has been just finding it and setting it on fire.

so why alla sudden is it obvious that this magical elixer exists?
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Re: Lab creates super mouse - twice as energy efficient

Unread postby lorenzo » Fri 02 Nov 2007, 18:23:09

$this->bbcode_second_pass_quote('aflurry', 'W')hat confounds me is the utter refusal to entertain the idea that there is no "new energy technology" to be found. The willingness to resort to this utterly superstitious idea that there IS an answer but we are just too stupid to find it. There has to be. There couldn't not be. "Of course" we will find it. We are too important to just disappear into the night.

Well we can and probably will just disappear into the night as great civilizations full of smart people before us have and for the same reasons.

And honestly, when you look at actual real technologies, there is some impressive tinkering - fair enough, but at base it all fails to live up to the hype. This is true particularly with the technologies of primary energy production, which i would characterize as the "technology of finding what else we got to burn." (paraphrasing from another member here, sadly.)

early on you had some nice innovation with windmills and waterwheels, but everything else has been just finding it and setting it on fire.

so why alla sudden is it obvious that this magical elixer exists?



Look, what's most efficient: transporting a 25 kilogram big brained head in a tiny vehicle, or transporting a 10kg head attached to a 70kg body in a 1500 kg car?

The human body is essentially an energy technology. We can make it far, far more efficient, requiring less food, less space, less energy.

And the brainier it becomes, the more efficient the energy technologies (including itself) it will develop.

The collective intelligence of 6 billion people with an IQ of 100 is considerably less potent that the collective intelligence of 60 billion brains with an IQ of 250.



PS: the super mice can eat more, because they can run far longer. It's about performance and metabolic efficiency.
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Re: Lab creates super mouse - twice as energy efficient

Unread postby aflurry » Fri 02 Nov 2007, 19:14:36

$this->bbcode_second_pass_quote('lorenzo', '
')The collective intelligence of 6 billion people with an IQ of 100 is considerably less potent that the collective intelligence of 60 billion brains with an IQ of 250.


As it relates to finding a "new energy technology" that is not there, this so called potency difference is exactly zero, because zero minus zero equals zero.


as for all this other wanking about the efficiency of humans themselves, evolution has your plans beat already. species adaptation has all that shit built in.
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Re: Lab creates super mouse - twice as energy efficient

Unread postby Pixie » Fri 02 Nov 2007, 19:49:30

$this->bbcode_second_pass_quote('lorenzo', '
')
PS: the super mice can eat more, because they can run far longer. It's about performance and metabolic efficiency.


Still, they don't do more with less. They do more with more. This article is in the opposite direction to your thinking, Lorenzo. These mice are not smarter, nor more efficient. They are just more powerful, and only because they can BURN MORE ENERGY FASTER! I can do the same with a whole lot of caffiene or steroids. This is just a really excellent doping technology. Very interesting from that perspective. Imagine human beings that can run three times longer and breed until they are 80 years old. Why, with metabolisms like that, we could overrun the entire solar system!

I have to agree with a couple of other posters. This thread is escapist sci-fi.
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Re: Lab creates super mouse - twice as energy efficient

Unread postby efarmer » Fri 02 Nov 2007, 21:16:07

Escapist sci-fi? With that attitude there won't be any super efficient mice ready to provide your "heads with legs" children a supply of riding and work animals. (Hope they make a palomino "sports" mouse!)

I enjoy Lorenzo's imagination and his positive slant very much, and think it is very key that we keep creating and imagining, even if it might be against very stiff opposition.

I do like these sort of threads because new thoughts and imaginations often lead to the synthesis that makes inventions and solutions happen in our "pool of brains". It takes courage to imagine in public and suffer the pot shots of smart asses (like me).


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Re: Lab creates super mouse - twice as energy efficient

Unread postby peak » Sat 03 Nov 2007, 03:29:53

Superior mice?

$this->bbcode_second_pass_quote('', 'T')he scientists found their new mice would eat twice as much as normal mice - but weigh half as much.


Huge disadvantage.

$this->bbcode_second_pass_quote('', 'I')t also lives longer, and breeds later in life compared with its standard laboratory cousin.


I don't see how mice breeding later in life as an advantage. These superior mice won't ever replace regular mice in the real world because of these disadvantages.

You can make a mouse run twice as far by making it fat. This is news?
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Re: Lab creates super mouse - twice as energy efficient

Unread postby pup55 » Sat 03 Nov 2007, 03:35:26

Wikipedia

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Re: Lab creates super mouse - twice as energy efficient

Unread postby lorenzo » Sat 03 Nov 2007, 13:08:07

$this->bbcode_second_pass_quote('peak', 'S')uperior mice?

$this->bbcode_second_pass_quote('', 'T')he scientists found their new mice would eat twice as much as normal mice - but weigh half as much.


Huge disadvantage.

$this->bbcode_second_pass_quote('', 'I')t also lives longer, and breeds later in life compared with its standard laboratory cousin.


I don't see how mice breeding later in life as an advantage. These superior mice won't ever replace regular mice in the real world because of these disadvantages.

You can make a mouse run twice as far by making it fat. This is news?


Stop sticking to fat mice leg. Think ahead.

I was talking about applying similar techniques to human brains.

With genetic engineering, we will will be able to increase the size of our brains, dump all unnecessary meat (like legs, arms and butts - uhm, ok, let's make an exception for women's butts) and concentrate on improving the efficiency and performance of our grey matter.

We can simply begin to decide to produce tiny people (see the thread about engineering nanopeople) with big heads. That's the easy part. Then we design an artificial intelligence system that can download, store, process and autonomously operate the data emerging from these brains.

Many scientists have been thinking of decentralising this system, by putting it on a broad range of planets (to make sure that all our work is stored somewhere safe).

We have then become independent of bulky materials - no need for bones, skulls, blood vessels, etc... all that old world stuff.

The final step is to keep making ever tinier "human presences", which will allow us to colonise other planets by the billions.

It is highly likely that we will end up as hyper-intelligent humanoid virii. You can thus create 6 billion people on a petri-dish, so to speak, and feed it with a drop of glucose. Cozy.
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Re: Lab creates super mouse - twice as energy efficient

Unread postby TheDude » Sat 03 Nov 2007, 14:33:22

$this->bbcode_second_pass_quote('lorenzo', 'W')ith genetic engineering, we will will be able to increase the size of our brains, dump all unnecessary meat (like legs, arms and butts - uhm, ok, let's make an exception for women's butts) and concentrate on improving the efficiency and performance of our grey matter.


Image

$this->bbcode_second_pass_quote('', 'W')e can simply begin to decide to produce tiny people (see the thread about engineering nanopeople) with big heads. That's the easy part. Then we design an artificial intelligence system that can download, store, process and autonomously operate the data emerging from these brains.


Image

Why don't we, uh, just upload what's in the brains we has? Uh, have, uh...uh, fire up the AI we've designed already, uh...

What the hell are you talking about? Weren't you banned last year anyway? Is the date codes on this topic not correct and we is reading a post from two year ago? Uh...

$this->bbcode_second_pass_quote('', 'M')any scientists have been thinking of decentralising this system, by putting it on a broad range of planets (to make sure that all our work is stored somewhere safe).


Oh come on. You're not serious, are you? You had me up until now with the tiny people with bowling ball heads, but really.

Wel, we know what happened to one of the Cornucopians.

Super Mouse? How about a Super Chicken?

Google Super Chicken and the first hit seems to be a porn site, too. Shudder...
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Re: Lab creates super mouse - twice as energy efficient

Unread postby Judgie » Sat 03 Nov 2007, 20:35:26

I can't help but notice the sudden re-appearance of all our missing technocornucoptimists since oil passed $90 a barrel. 8)
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Re: Lab creates super mouse - twice as energy efficient

Unread postby lorenzo » Sat 03 Nov 2007, 20:57:28

$this->bbcode_second_pass_quote('Judgie', 'I') can't help but notice the sudden re-appearance of all our missing technocornucoptimists since oil passed $90 a barrel. 8)


It's not that strange. As oil gets more expensive, more money goes into our thermonuclearopiadistic ideas.

From $100 onwards more people are going to say: this stupid stuff called oil, let's get rid of it once and for all.

And then you'll see ever more efficient tiny nice little reactors and devices and such appearing on the market.

That's how it works.

We're only beginning, the age of abundant clean energy is only beginning to emerge, and you're already complaining! Give us some slack.
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