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THE Pharmacy / Pharmaceutical Thread (merged)

Discussions related to the physiological and psychological effects of peak oil on our members and future generations.

Prescription drugs: The God That Failed

Unread postby cador » Sun 05 Dec 2004, 11:24:32

Americans are the most over-medicated people in the world. Hence, the drug companies work hard to make sure that Americans pay the highest drug costs in the world as well.

Many smart people are figuring out that the drug companies are no better than the witch doctors from the days of old. Most people when they hear the magic words "New scientific studies have shown that Drug X is good for your health and that Vitamin C causes cancer" they store that little nugget inside their little heads and proclaim it as gospel.

http://apnews.myway.com/article/20041204/D86P2IH01.html

Vitamins represent the greatest threat to the pharmaceutical establishment. Why are they working overtime to ban the sale of natural vitamins and herbs?

http://curezone.com/forums/m.asp?f=237&i=597
Last edited by Ferretlover on Wed 01 Apr 2009, 09:45:38, edited 1 time in total.
Reason: Merged with THE Pharmacy / Pharmaceutical Thread.
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Unread postby ailrickson73 » Sun 05 Dec 2004, 12:26:24

Is there anything in this world that isn't a racket?

I agree Mr. Cador, that the stance on banning vitamins is ridiculous. I give my kids vitamins every day.

Cough sirop is not a cure for the cold, it simply alleviates the symptoms until the body rids itself of the disease. That is a popular misconception, and I am certain that if researched many other examples of this type can be found. Publicity tries to sell things, not tell the truth.

Good point. You advance another silver liging to peak oil. Once the SHTF, companies will not be able to afford to advertise these things, and people will not be able to buy new TVs to hear them even if they did.
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Unread postby Specop_007 » Sun 05 Dec 2004, 12:49:04

Actually, Americas medical costs are so high because we foot the bill for the R&D for the rest of the world.
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Unread postby giengreen » Sun 05 Dec 2004, 15:51:08

We also sell to the rest of the world and domesticly recouping that money with profits, else big Pharma would not be in Business to begin with.
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Unread postby MarkR » Sun 05 Dec 2004, 18:17:41

Prescription drugs are expensive, because R&D is expensive. Currently, it costs around $250-$400 million to develop a new medication and bring it to market. Because of the time limits on patents and length of development, the company may only have 5-8 years monopoly on that drug during which it has to recoup its investment.

Another part of the reason that US drug costs are so high is because litigation within the US is so high.

The big pharma companies have 'legal funds' which are used to defend them if they are sued because of a drug. Some lawsuits are inevitable, because it is impossible to identify all side-effects, especially rare ones, before a drug is released onto the open market.

In the US, it's common for prescription drugs to be twice the price of the same drug, from the same company, in other countries - the difference is in the 'insurance premium' that is paid into the defence fund.

$this->bbcode_second_pass_quote('', 'W')hy are they working overtime to ban the sale of natural vitamins and herbs?


Just because something is natural, doesn't mean it is safe.

Vitamins are essential nutrients, but excessive consumption (in unnatural doses) can be harmful. Low-dose vitamin supplements are generally safe, although are not necessary for the vast majority of people. Yet, it's not uncommon to see high-dose vitamin preparations offered as supplements. At some of the doses offered there are genuine health risks from vitamins, and there are recognised syndromes of vitamin poisoning.

The EU directive, discussed above, does not ban the production of supplements, it only limits the ingredients to those known to be safe, and limits the doses to safe prescribed levels. I cannot see anything in the proposed legislation that would outlaw the sale of safe vitamin supplements.

Herbal remedies are a seperate issue, but currently sale of herbal remedies is essentially unregulateed. When you sell a herbal remedy you do not need to be able to prove that it works, and you do not need to prove that it is safe, you do not have to test the dose in each batch, nor indeed do you have to test whether there is any active ingredient at all. (All these safeguards are mandatory before a prescription medication can be sold).

There are a number of herbal remedies, with potent pharmacological effects (e.g. St John's wort) and their use requires the same level of care as prescription drugs. In fact SJW is notorious for it's long list of side-effects, and potentially fatal interactions with other medications and certain illnesses.

A review of the sale of herbal remedies is sorely needed.
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Unread postby smiley » Sun 05 Dec 2004, 18:51:51

$this->bbcode_second_pass_quote('', 'I') agree Mr. Cador, that the stance on banning vitamins is ridiculous. I give my kids vitamins every day.


Did you know that vitamin overdose is the most common cause of infant poisoning deaths among infants in the US as well as in Europe? A lot of these deaths are caused by parents which are not aware that vitamins can have unhealthy effects.

Indeed the media campaign around the multivits and the food supplements seem to suggest that the more vitamins you take the healthier you become. The reality is that we are already consuming a more than enough vitamins and that children are now frequently subjected to an overdose of vitamins.

Vitamins are a drug and like most drugs there is a fine line between a healthy, unhealthy or even lethal dose. More than 10 mg of iron per kilogram of bodyweight (about 5 pills) will kill your child just as easily as your average cleaning agent. Too much vitamin A has bad and irreversible effects on your child's liver. It will eventually kill your child. Calcium will also cause permanent damage to your child's kidneys.

That doesn't mean that vitamins are bad, just that you need to handle them with care like every drug. You have to read the label on the bottle and to take care that your child's intake does not exceed the allowed limit.

And when you do please take care of the bodyweight factor. For a child that weighs six time less than you do the maximum dose will also be six time less. Therefore never give a young child multivitamins that are designed for adults.

I'm sure that you use vitamins in a responsible way, but please realize that the task of monitoring your child's vitamin intake becomes increasingly difficult when manufacturers start putting vitamin supplements in their food. Do you for instance know how much energy bars your child eats? Nowadays these bars contain as much vitamins as the supplement pills themselves.

Therefore I don't think it is a good idea to put vitamins in food and I support this ban.

If you think that I'm overreacting please ask your local doctor and he will confirm this story. Alternatively just google for vitamin poisoning and you'll get all the information you need.
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Unread postby cador » Mon 06 Dec 2004, 13:43:09

Great website about Vitamin C and cancer:
http://lpi.oregonstate.edu/

Oh, and what do you all think of the Vioxx scandal? I mean, i thought that the pharmaceuticals were our friends?
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Unread postby MarkR » Mon 06 Dec 2004, 15:25:38

I have to confess, that I've not looked into the Vioxx issue that closely. I don't know if there was evidence of cover-up or not, as I'm not really in a position to find out.

As I understand it, a study incidentally found that vioxx was associated with an increased risk of stroke and heart attack compared to not taking it. This was a side effect that pre-marketing studies on 5000 people had not demonstrated, nor had routine post-launch surveillance (where doctors are advised to report possible side effects, for new drugs, even if they are unsure).

When this incidental finding came to light, the manufacturer immediately withdrew the drug from sale, without even a request from the FDA.

It's difficult to cast blame on MSD for their actions, from this perspective. In the absence of evidence of harm, and lots of evidence for significant benefit (vioxx is a much safer drug than alternatives like advil), it seems reasonable that it should have got approval for use.

Perhaps the blame could be cast on the FDA for approving the drug based on an insufficiently large study - especially for a drug that had such an enormous market, and therefore opportunity to harm. However, you have to accept that the size of pre-launch studies is limited, and that rare side-effects are not always identifiable in such studies.
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Unread postby cador » Mon 06 Dec 2004, 18:40:26

$this->bbcode_second_pass_quote('MarkR', 'T')he EU directive, discussed above, does not ban the production of supplements, it only limits the ingredients to those known to be safe, and limits the doses to safe prescribed levels. I cannot see anything in the proposed legislation that would outlaw the sale of safe vitamin supplements.


The other day I had a nasty flu. I consumed about 6000 mg of vitamin C that day and the next day I woke up feeling much better. Now, I would consume the entire 6000 mg by taking it in several portions throughout the day.

Did the vitamin C help with my condition? Maybe yes, maybe no. Perhaps it was the 12 continuous hours of bed rest which really did the trick. Maybe it was a little bit of both. Well, in the old days where I relied on NyQuil, NeoCitran and other cold remedies I spent upwards of $10-$20 to fight my cold/flu.

The EU directive if applied to North America would make it impossible for me to buy Vitamin C in 500 mg tablets. I would be forced to buy 90 mg tablets at pretty much the same price. Anything higher than that would require a prescription and force me to buy the 500mg tablets from big Pharmacare.

The story of Linus Pauling is a great one. He had gotten stomach cancer and he kept his cancer in remission for 30 years by taking 20,000 mg of vitamin C every day. He did eventually die of stomach cancer -- at the ripe young age of 94.

Vitamin C is a miracle immune system booster. The big pharmaceuticals want it banned because they want ordinary people to buy the prescription drugs their doctors prescribe them.
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Unread postby MarkR » Mon 06 Dec 2004, 19:44:30

$this->bbcode_second_pass_quote('', 'V')itamin C is a miracle immune system booster. The big pharmaceuticals want it banned because they want ordinary people to buy the prescription drugs their doctors prescribe them.


You are welcome to your belief, but there are no credible scientific studies that suggest immune boosting from large doses of Vitamin C. Equally, there are no good studies that demonstrate a reduction in the severity or duration of colds or 'flu, nor any studies that demonstrate any benefit in gastric, or any other, cancer.

There are lots of reports or studies which are oft quoted by proponents of vitamin C therapy - however, their value is debateable at best due to small study sizes, or their study methods are severely flawed (e.g. uncontrolled or poorly blinded studies).

The story of Linus Pauling is a tragic one. He was a truely brilliant scientist, but in his later years he developed an obsessive fascination with Vitamin C. The result was that his belief in the benefits of Vit C were simply delusions - which studies have tried, but failed, to replicate. He remained deluded to the end, claiming that his prostate cancer had been kept in remission for 30 years - despite him first being diagnosed at the age of 93.

It's fortunate that vitamin C is of very low toxicity, so it is essentially impossible to overdose - however, long term use does pre-dispose to kidney stones, so excessive consumption is not recommended. There is no scientific basis to take more than about 200 mg per day.
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Unread postby TheSupplyGuy » Mon 06 Dec 2004, 22:19:09

What about the antioxidant benefits of vitamin C? Instead of oxygen breaking down your cells, it instead reacts wiht your excess vitamin C, somewhat sparing you from its harmful effects. Go to any medical research site and it will say vitamin C is an antioxidant.
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Unread postby smallpoxgirl » Mon 06 Dec 2004, 23:30:07

$this->bbcode_second_pass_quote('MarkR', 'P')rescription drugs are expensive, because R&D is expensive.


That is completely untrue. American drug companies are spending more on advertising than they are for R&D, producing drugs, and distributing drugs combined.

See: http://www.nofreelunch.org/factsfallacies.htm

Prescription drugs are so expensive because of all the ads on television. The drug companies are making a killing, the media corporations are making a killing, and sick people are sucking up the costs.

In fact in a lot of cases the perversity of it is that the drugs aren't that expensive. Your doctor is writing for a $100 drug when a $10 one would do fine because the rep for the $100 drug bought his breakfast.
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Unread postby Specop_007 » Tue 07 Dec 2004, 05:06:45

$this->bbcode_second_pass_quote('smallpoxgirl', '')$this->bbcode_second_pass_quote('MarkR', 'P')rescription drugs are expensive, because R&D is expensive.


That is completely untrue. American drug companies are spending more on advertising than they are for R&D, producing drugs, and distributing drugs combined.

See: http://www.nofreelunch.org/factsfallacies.htm

Prescription drugs are so expensive because of all the ads on television. The drug companies are making a killing, the media corporations are making a killing, and sick people are sucking up the costs.

In fact in a lot of cases the perversity of it is that the drugs aren't that expensive. Your doctor is writing for a $100 drug when a $10 one would do fine because the rep for the $100 drug bought his breakfast.


Really? Doctors I've talked to who went overseas seem to disagree with your sentiments. Take an operation which cost X dollars, that same one costs Y in Canada and Z in a place such as Iran or Suadi.
And everytime its X > Y > Z

Now why is the SAME THING cheaper in countries with less money? Because we foot the R&D.
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Unread postby Specop_007 » Tue 07 Dec 2004, 05:08:14

I forgot to add, thats not to say marketing isnt an added cost.
But you cant market what you dont have. Its that simple. If they dont keep the R&D churning out new products, marketing doesnt have much to do.
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Unread postby PhilBiker » Tue 07 Dec 2004, 10:46:23

You've all missed what I personally feel is the real issue.

I have no studies and no links or anything go back this belief up except simple observation of the world around me.

There are many factors, but the deep underlying reason medical technology, all medical technology, not jusy Rx drugs, is so expensive is the following: We have reached the point of diminishing returns. Much like with peak oil, we've reached the point where we have to invest huge amounts of effort and massive amounts of money into advancing medical research even a little bit. There will never be another "miracle cure" like the discovery of pennicilin or the Polio vaccene or anything else. We've already found all the "low hanging fruit" in the medical field.

Plus, the whole world is missing the poing. We're toxifying the world with chemicals and we wonder why cancer rates are going up. Instead of researching the new toxicity of the world around us, we're spending umpteen million dollars trying to find a cure for breast cancer.

There will never be a cure for cancer. There will never be a cure for AIDS. There will never be a cure for most things we're working on. When does it end? When does the research into these lost causes end? When do we realize that the medical world has reached the practical end of the line?
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Unread postby cador » Tue 07 Dec 2004, 10:50:55

$this->bbcode_second_pass_quote('Specop_007', 'R')eally? Doctors I've talked to who went overseas seem to disagree with your sentiments. Take an operation which cost X dollars, that same one costs Y in Canada and Z in a place such as Iran or Suadi.
And everytime its X > Y > Z

Now why is the SAME THING cheaper in countries with less money? Because we foot the R&D.


What's really sad is that the US government spends more per capita on health care than any other country in the world.

The problem with the US health system is that:

-lawyers are suing hospitals and doctors
-many non-American citizens receive free health care at the cost of the US taxpayer
-the uninsured have to pay more than what the hospitals will charge the health insurance companies for basically the same services
-the underlying belief that prescription drugs will cure all ills

In many ways the US middle class are like Atlas, they carry the weight of the world, big business and the cost of social programs for the underclass. AIDS sufferers in the US have to pay hundreds of dollars a month for a cocktail drug (made from AZT a chemo drug invented in the 1950s) while these same drug companies are selling them for cheaper in AFrica. George Bush promised to give $10 billion to help AIDS in Africa, but am I the only one who sees this as a boondoggle to subsidize the AIDS pharmaceutical industry? (how much of that money is going to be used to buy the expensive AIDS drugs from Pharmaco to give to Africa?)

If the US really has to pay the R&D costs for the rest of the world, I would recommend that the US citizens lead a large-scale revolt against the pharmaceutical companies. I think it would be a good thing if Atlas shrugged his shoulders in this case.
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Unread postby trespam » Tue 07 Dec 2004, 11:17:23

Debates like this are always interesting. Everyone has their canned set of answers. The conservatives say too many lawyers, companies are wonderfull fuzzy loving creatures that want to do good, etc etc. Liberals say companies are evil, innovations are created in government funded universities, etc etc.

The truth is probably somewhere in between. If you look at the survival rate over a variety of criteria, the us health care system is not very cost effective. I think we spend inordinate amounts of money on the last 20% of a problem when we'd be better off spending more funds on the 80% core problems. Americans are obsessed with convenience. Convenience is nice, but extremely wasteful. Americans hate to wait. I think that is the American sickness that has been broadcast far and wide to the rest of the world. If anything dies, let's hope this obsession with speed does.

I'm not sure it's true that Americans are more overmedicated. The Japanese are pill poppers. A woman I know in China, a professional, says it's impossible to see a doctor so people just purchase pills after self-diagnosing.
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Unread postby Specop_007 » Tue 07 Dec 2004, 11:22:08

$this->bbcode_second_pass_quote('trespam', 'D')ebates like this are always interesting. Everyone has their canned set of answers. The conservatives say too many lawyers, companies are wonderfull fuzzy loving creatures that want to do good, etc etc. Liberals say companies are evil, innovations are created in government funded universities, etc etc.

The truth is probably somewhere in between. If you look at the survival rate over a variety of criteria, the us health care system is not very cost effective. I think we spend inordinate amounts of money on the last 20% of a problem when we'd be better off spending more funds on the 80% core problems. Americans are obsessed with convenience. Convenience is nice, but extremely wasteful. Americans hate to wait. I think that is the American sickness that has been broadcast far and wide to the rest of the world. If anything dies, let's hope this obsession with speed does.

I'm not sure it's true that Americans are more overmedicated. The Japanese are pill poppers. A woman I know in China, a professional, says it's impossible to see a doctor so people just purchase pills after self-diagnosing.


Removing the spin and rant... (sorry, couldnt resist) :P

I do agree, its seems to be about convienience. A perfect example is those makeover TV shows. God how I hate those. They take some not so attractive female, and through the marvels of modern surgury turn her into a ready made super model. I sit and watch and think Jesus people, get your FAT ASS off the couch, quit eating 4 candy bars a day and work out! But people dont want to put any effort into it. They simply want results NOW, without all that tedious ho hum work that goes on in between the now and the result stage. Its ridiculous, and sad. To think we've become so self obssessed and so shallow that we cant even put in an honest effort to change that which bothers us.
So, that particular view extands well beyond the medical field, and seems to be the prevalent view of the American Society. Que Dire Straits... Money For Nothing, and the chicks for free.
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Unread postby trespam » Tue 07 Dec 2004, 11:34:11

$this->bbcode_second_pass_quote('Specop_007', 'I') do agree, its seems to be about convienience. A perfect example is those makeover TV shows. God how I hate those.


[rant]
This is an aspect of American society that I find appalling. The something for nothing attitude. The "I deserve it" attititude. And it's not the poor, not the rich, not the middle class. It's a large percentage of people across the board. Irrespective of party or class. They are the whiners. I think there is an expectation of perfection, that somehow life somehow must be perfect for "me", for "my kid"--I find it very annoying.

I was in a school meeting and one of the parents, a whiner--I know from experience--was complaining that "his daughter this" and "his daughter that" and the school wasn't meeting her needs--apparently she's above average--and isn't it funny that maybe 80% or so of the public think they are above average. Hmmm. Problem there. So this guy is complaining and finally I comment that the public schools are no in the business of meeting every particular need of every particular kid. It's impossible. Get a private teacher.

The NYT took a look at American consumers this past week. Rushing out to buy crap for xmas. Now tell me this isn't a corporate plot. Mindless idiots running around buying crap for someone, often someone they can't stand, and often enough the receiver of the crap can't stand what they get. If the corporations didn't invent xmas, they should have.

[/end rant]
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Unread postby Specop_007 » Tue 07 Dec 2004, 11:39:26

Christmas.... Man, thats a whole post in and of itself. Corporations and advertising have turned Christmas from a childhood memory of snow, decorating trees, family, food, loved ones and rpesents under the tree into who can buy the most the fastest. God, I hate, I despise, I loath what Christmas has become. And the change has (fortunately perhaps) been relatively new and quick. I'm certainly not old by any stretch, and I can remember a "simpler" Christmas as it were, where the idea of Christmas was family and the joy of presents rather then some advertising fuled rush for THAT toy that EVERYONE MUST HAVE. Hell, Thanksgiving has almost become a afterthought to the Christmas rush. Even as early as October and Halloween people are gearing up for Christmas.....
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